Skip to main content

Lipid Mediators

  • Reference work entry
  • First Online:
Encyclopedia of Cancer

Synonyms

Bioactive lipids; Lipid second messengers

Definition

Lipid mediators are bioactive molecules rapidly produced upon cell activation either by enzymatic process or by oxidative fragmentation of polyunsaturated fatty acids attached to their glycerol backbone. The majority of lipid mediators are products of degradation and/or phosphorylation/dephosphorylation of glycerophospholipids by defined enzymes acting in concert and commonly designated as phospholipases (PLs), phosphokinases, and phosphatases. Hydrolysis of phospholipids also generates free fatty acids, including arachidonate, a direct precursor of eicosanoids.

Characteristics

Within seconds after cell activation, certain phospholipids are either selectively hydrolyzed by defined phospholipases leading to highly bioactive molecules (lipids and/or fatty acids) or phosphorylated by specific kinases to bioactive phosphoinositides Inositol lipids. Essentially three phospholipase (PL) families, namely, Phospholipase A2 (PLA2), Ph...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 2,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Segui B, Andrieu-Abadie N, Jaffrezou JP et al (2006) Biochim Biophys Acta 1758:2104–2120

    Article  CAS  PubMed  Google Scholar 

  2. Lee KW, Lee HJ, Cho HY et al (2005) Crit Rev Food Sci Nutr 45:135–144

    Article  CAS  PubMed  Google Scholar 

  3. Mills GB, Moolenaar WH (2003) Nat Rev Cancer 3:582–591

    Article  CAS  PubMed  Google Scholar 

  4. Rossi DJ, Weissman IL (2006) Cell 125:229–231

    Article  CAS  PubMed  Google Scholar 

  5. Ulrich CM, Bigler J, Potter JD (2006) Nat Rev Cancer 6:130–140

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Ninio, E. (2011). Lipid Mediators. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_3372

Download citation

Publish with us

Policies and ethics