Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

ABC-Transporters

  • Hermann LageEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_13

Synonyms

Definition

ABC (ATP-binding cassette)-transporters are membrane-embedded proteins with a characteristic ABC domain that utilize the energy from ATP hydrolysis for the transport of their substrates across a cellular membrane.

Characteristics

The superfamily of ABC-transporters comprises one of the most abundant protein families in nature. These transporters are believed to date back in evolutionary time more than 3 billion years and are distributed in all three kingdoms of living organisms, archaea, eubacteria, and eukaryotes. ABC-transporters have to be distinguished from ABC-proteins. Both types of proteins are defined by the presence of a highly conserved ∼215 amino acids consensus sequence designated as ABC domain or nucleotide-binding domain (NBD). The domain contains two short peptide motifs, a glycine-rich Walker A and a hydrophobic Walker B motif, both involved in ATP binding and...
This is a preview of subscription content, log in to check access.

References

  1. 1.
    Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2:48–58PubMedCrossRefGoogle Scholar
  2. 2.
    Higgins CF (1993) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:7–113Google Scholar
  3. 3.
    Holland IB, Cole SPC, Kuchler K, Higgins CF (eds) (2003) ABC proteins from bacteria to man. Academic/Elsevier, London/San DiegoGoogle Scholar
  4. 4.
    Lage H (2003) ABC-transporters: implications on drug resistance from microorganisms to human cancers. Int J Antimicrob Agents 22:188–199PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Institute of PathologyBerlinGermany