Definition
CDC refers to the lysis of a target cell in the presence of complement system proteins. The complement activation pathway is initiated by the binding and fixation of the first component of the complement system (CIq) to the fragment crystalline (Fc) region of a (therapeutic) antibody complexed with a cognate antigen. The end result is a membrane attack complex that generates a hole in the cell membrane, ultimately causing cell lysis and death.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Complement-Dependent Cytotoxicity. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_1286
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DOI: https://doi.org/10.1007/978-3-642-16483-5_1286
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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