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Handbook of Particle Detection and Imaging pp 1125–1151Cite as

High-Resolution and Animal Imaging Instrumentation and Techniques

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Abstract

During the last decade we have observed a growing interest in “in vivo” imaging techniques for small animals. This is due to the necessity of studying biochemical processes at a molecular level for pharmacology, genetic, and pathology investigations. This field of research is usually called “molecular imaging.”Advances in biological understanding have been accompanied by technological advances in instrumentation and techniques and image-reconstruction software, resulting in improved image quality, visibility, and interpretation. The main technological challenge is then the design of systems with high spatial resolution and high sensitivity.

This chapter gives a short overview of the state-of-the-art technologies for high-resolution and high-sensitivity molecular imaging techniques, namely, positron emission tomography (PET) and single photon emission computed tomography (SPECT) as well as the basics of small-animal x-ray computed tomography (CT). Multimodality techniques merging molecular information with anatomical details are also introduced. Finally, the new trends in detector technology for other high-resolution applications like breast cancer investigation are presented.

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Authors and Affiliations

  1. Department of Physics “E. Fermi”, University of Pisa, Largo B. Pontecorvo 3, I-56127, Pisa, Italy

    Nicola Belcari

  2. Department of Physics “E. Fermi”, University of Pisa, Largo B. Pontecorvo 3, I-56127, Pisa, Italy

    AlbertoDel Guerra

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  1. Nicola Belcari
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  2. AlbertoDel Guerra
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Editors and Affiliations

  1. Department of Physics, Siegen University, Emmy-Noether-Campus, Walter-Flex-Str. 3, 57072, Siegen, Germany

    Claus Grupen

  2. IMNC-UMR 8165 CNRS, Paris 7 and Paris 11 Universities, Orsay Campus, Building 440, 91406, Orsay Cedex, France

    Irène Buvat

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Belcari, N., Guerra, A. (2012). High-Resolution and Animal Imaging Instrumentation and Techniques. In: Grupen, C., Buvat, I. (eds) Handbook of Particle Detection and Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13271-1_45

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