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p-RNA

  • Reference work entry
Encyclopedia of Astrobiology

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Synonyms

Pentopyranosyl-RNA; Pyranosyl-RNA

Keywords

Base-pairing, heterochiral, homochiral, nucleic acid, oligonucleotides, pentopyranose, Watson–Crick

Definition

Pyranosyl-RNA (“p-RNA”) is an oligonucleotide in which the ribose units exist in the pyranose form and are linked together repetitively by phosphodiester groups between the hydroxyl groups at positions C-2′ and C-4′ (Fig. 1).

p-RNA. Figure 1
figure 1639

A constitutional and a (idealized) conformational representation of pyranosyl-RNA (p-RNA); BASE = adenine, guanine, 2,6-diaminopurine, iso-guanine, thymine, cytosine, and uracil

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References and Further Reading

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  • Bolli M, Micura R, Eschenmoser A (1997b) Pyranosyl-RNA: chiroselective self-assembly of base sequences by ligative oligomerization of tetra nucleotide-2′, 3′-cyclophosphates (with a commentary concerning the origin of biomolecular homochirality). Chem Biol 4:309–320

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  • Eschenmoser A (1993a) Hexose nucleic acids. Pure Appl Chem 65: 1179–1188 (Lecture at the “18th IUPAC Symposium on the Chemistry of Natural Products,” Strasbourg/F, August 1992)

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  • Eschenmoser A (1993b) Toward a chemical etiology of the natural nucleic acids’ structure. In: Proceedings of the Robert A. Welch foundation 37th conference on chemical research 40 years of the DNA double helix. Robert A. Welch Foundation, Houston, TX, USA, 201–235

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  • Eschenmoser A (1996) Towards a chemical etiology of the nucleic acids structure. Orig Life Evol Biosph 27:535–553

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  • Micura R, Bolli M, Windhab N, Eschenmoser A (1997) Pyranosyl-RNA also forms hairpin structures. Angew Chem Int Ed 36:870–873

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Author information

Authors and Affiliations

  1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA

    Prof. Ramanarayanan Krishnamurthy, Dr. Sagi Vasudeva Naidu & Dr. Venkateshwarlu Punna

Authors
  1. Prof. Ramanarayanan Krishnamurthy
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  2. Dr. Sagi Vasudeva Naidu
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  3. Dr. Venkateshwarlu Punna
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Corresponding author

Correspondence to Ramanarayanan Krishnamurthy .

Editor information

Editors and Affiliations

  1. Astrophysicist, Laboratoire d’Astrophysique de Bordeaux, BP 89, 33270, Floirac, France

    Muriel Gargaud

  2. Departamento de Planetología y Habitabilidad Centro de Astrobiología (CSIC-INTA), Universidad Autónoma de Madrid Campus Cantoblanco, Torrejón de Ardoz, 28049, Madrid, Spain

    Ricardo Amils

  3. Department of Astrophysics, Centro de Astrobiología (INTA-CSIC) Ctra de Ajalvir km 4, 28850 Torrejón de Ardoz, Madrid, Spain

    José Cernicharo Quintanilla

  4. Geophysical Laboratory, Carnegie Institution of Washington, 5251 Broad Branch Rd. NW, Washington, DC, 20015, USA

    Henderson James (Jim) Cleaves II

  5. Department of Astronomy, University of Massachusetts Lederle Graduate Research, 710 North Pleasant Street, Amherst, MA, 01003-9305, USA

    William M. Irvine

  6. GEOTOP & Départment des Sciences de la Terre et de l’Atmosphère, Université du Québec à Montréal, CP 8888, succ. Centre-Ville, Montréal, QC, H3C 3P8, Canada

    Daniele L. Pinti

  7. Astrobiology, CNES/DSP/EU, 2 place Maurice-Quentin, 75039, Paris, France

    Michel Viso

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Krishnamurthy, R., Naidu, S.V., Punna, V. (2011). p-RNA. In: Gargaud, M., et al. Encyclopedia of Astrobiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11274-4_1277

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