Introduction
Essential to the efficacy of performance of drug delivery systems is the ability of the drug to diffuse from the said delivery systems and dissolve within the biological medium. Following this, the drug may diffuse through the biological media and subsequently diffuse across the attendant biological membranes, thereby gaining entry into the systemic circulation. In certain systems, the rate at which the drug dissolves within the biological fluid is the slowest and hence the rate-limiting step whereas in other scenarios the diffusion of the drug across the biological membrane may present the greatest challenge. In light of the importance of drug release, it is essential to ensure that the statistical analysis of the data from such experiments is successfully performed to enable rational conclusions to be drawn.
The conductance and design of drug release experiments is relatively straightforward and is defined within the scientific literature and within Pharmacopoeial...
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Baker RW (1987) Controlled release of biologically active agents. Wiley-Interscience, New York
Bolton S, Bon C (2004) Pharmaceutical statistics: practical and clinical applications, vol 135. Marcel Dekker, New York, p 755
Chien YW (1992) Novel drug delivery systems, 2nd edn. vol 50. Marcel Dekker, New York
Jones DS (2002) Pharmaceutical statistics. Pharmaceutical Press, London, p 608
Jones DS, Irwin CR, Woolfson AD, Djokic J, Adams V (1999) Physicochemical characterization and preliminary in vivo efficacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis. J Pharm Sci 88(6):592–598
Jones DS, Woolfson AD, Brown AF, Coulter WA, McClelland C, Irwin CR (2000) Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Cont Rel 67(2–3):357–368
Peppas NA (1985) Analysis of Fickian and Non-Fickian drug release from polymers. Pharm Acta Helvet 60(4):110–111
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© 2011 Springer-Verlag Berlin Heidelberg
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Jones, D.S. (2011). Statistical Analysis of Drug Release Data Within the Pharmaceutical Sciences. In: Lovric, M. (eds) International Encyclopedia of Statistical Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04898-2_624
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DOI: https://doi.org/10.1007/978-3-642-04898-2_624
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