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Retinoids

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Kanerva's Occupational Dermatology
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Abstract

Vitamin A derivatives have revolutionized dermatologic treatment.

The immune modulating, antiproliferative, and anti-inflammatory efficacy of retinoids is mediated by two nuclear receptor families: retinoic acid receptors and retinoid X receptors.

Vitamin A derivatives can be classified due to their receptor-binding profile, their belonging to different generations of retinoids, or their mode of application.

Due to their teratogenic potential, safe contraception with adequate methods prior, during, and after treatment with systemic and some topical retinoids according to current national guidelines is absolutely mandatory.

With appropriate and careful therapeutic management by a physician familiar with retinoid use, vitamin A derivatives can be effective treatment options for many dermatologic disorders.

Relevant retinoid-responsive diseases in occupational dermatology are, for example, acne, psoriasis, and chronic refractory hand eczema.

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References

  • Berkers JA, Hassing I, Spenkelink B et al (1995) Interactive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoids on proliferation and differentiation in cultured human keratinocytes: quantification of cross-linked envelope formation. Arch Toxicol 69:368–378

    Article  PubMed  CAS  Google Scholar 

  • Bollag W, Ott F (1999) Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid. Dermatology 199:308–312

    Article  PubMed  CAS  Google Scholar 

  • Chandraratna RAS, Klein ES (1998) Retinoid nuclear receptors. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Cheng C, Michaels J, Scheinfeld N (2008) Alitretinoin: a comprehensive review. Expert Opin Investig Drugs 17:437–443

    Article  PubMed  CAS  Google Scholar 

  • Connor MJ (1998) Mechanisms of retinoid action in the skin. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Duvic M, Hymes K, Heald P et al (2001a) Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results. J Clin Oncol 19:2456–2471

    PubMed  CAS  Google Scholar 

  • Duvic M, Martin AG, Kim Y et al (2001b) Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch Dermatol 137:581–593

    PubMed  CAS  Google Scholar 

  • Fowler JF (1999) Acne, folliculitis, and chloracne. In: Adams RM (ed) Adams occupational skin disease, 3rd edn. W.B. Saunders, Philadelphia

    Google Scholar 

  • Freeman S (1999) Diagnosis and differential diagnosis. In: Adams RM (ed) Adams occupational skin disease, 3rd edn. W.B. Saunders, Philadelphia

    Google Scholar 

  • Ganceviciene R, Zoubulis C (2010) Isotretinoin: state of the art treatment for acne vulgaris. Acne Today J Dtsch Dermatol Ges Suppl 1:S47–S59

    Google Scholar 

  • Gauwerky K, Klövekorn W, Korting HC et al (2009) Rosacea. J Dtsch Dermatol Ges 7:996–1003

    PubMed  Google Scholar 

  • Grahovac M, Molin S, Prinz JC et al (2009) Treatment of atopic eczema with oral alitretinoin. Br J Dermatol 162:217–218

    Article  PubMed  Google Scholar 

  • Griffiths CE (2001) The role of retinoids in the prevention and repair of aged and photoaged skin. Clin Exp Dermatol 26:613–618

    Article  PubMed  CAS  Google Scholar 

  • Heald P, Mehlmauer M, Martin AG et al (2003) Topical bexarotene therapy for patients with refractory or persistent early-stage cutaneous T-cell lymphoma: results of the phase III clinical trial. J Am Acad Dermatol 49:801–815

    Article  PubMed  Google Scholar 

  • Kontaxakis VP, Skourides D, Ferentinos P et al (2009) Isotretinoin and psychopathology: a review. Ann Gen Psychiatry 8:2

    Article  PubMed  Google Scholar 

  • Lebwohl M, Drake L, Menter A (2001) Consensus conference: acitretin in combination with UVB or PUVA in the treatment of psoriasis. J Am Acad Dermatol 45:544–553

    Article  PubMed  CAS  Google Scholar 

  • Lee CS, Li K (2009) A review of acitretin for the treatment of psoriasis. Expert Opin Drug Saf 8:769–779

    PubMed  CAS  Google Scholar 

  • Lowe NJ (1998a) Keratinization disorders. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Lowe NJ (1998b) Psoriasis: systemic retinoid treatment. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Lowe NJ, David M (1998) Toxicity. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Marks R (1998a) Acne and related disorders. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Marks R (1998b) Lichen planus and cutaneous lupus erythematosus. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Marks R, Lowe NJ (1998) Topical retinoids for psoriasis. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Molin S, Ruzicka T (2008) Alitretinoin: a new treatment option for chronic refractory hand eczema [Review]. Hautarzt 59:703–709

    Article  PubMed  CAS  Google Scholar 

  • Molin S, Ruzicka T (2009) Possible benefit of oral alitretinoin in T-lymphoproliferative diseases: a report of two patients with palmoplantar hyperkeratotic-rhagadiform skin changes and mycosis fungoides or Sézary syndrome. Br J Dermatol 161:1420–1422

    Article  PubMed  CAS  Google Scholar 

  • Molin S, Ruzicka T (2010) Oral alitretinoin in lichen planus: two case reports. Acta Derm Venereol 90(5):523–524

    Article  PubMed  Google Scholar 

  • Ruzicka T, Meurer M, Bieber T (1988) Efficiency of acitretin in the treatment of cutaneous lupus erythematosus. Arch Dermatol 124:897–902

    Article  PubMed  CAS  Google Scholar 

  • Ruzicka T, Sommerburg C, Braun-Falco O et al (1990) Efficiency of acitretin in combination with UV-B in the treatment of severe psoriasis. Arch Dermatol 126:482–486

    Article  PubMed  CAS  Google Scholar 

  • Ruzicka T, Sommerburg C, Goerz G et al (1992) Treatment of cutaneous lupus erythematosus with acitretin and hydroxychloroquine. Br J Dermatol 127:513–518

    Article  PubMed  CAS  Google Scholar 

  • Ruzicka T, Larsen FG, Galewicz D et al (2004) Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol 140:1453–1459

    Article  PubMed  CAS  Google Scholar 

  • Ruzicka T, Lynde CW, Jemec GB et al (2008) Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol 158:808–817

    Article  PubMed  CAS  Google Scholar 

  • Thestrup-Pedersen K, Andersen KE, Menné T et al (2001) Treatment of hyperkeratotic dermatitis of the palms (eczema keratoticum) with oral acitretin. A single-blind placebo-controlled study. Acta Derm Venereol 81:353–355

    Article  PubMed  CAS  Google Scholar 

  • Thielitz A, Gollnick H (2008) Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol 9:369–381

    Article  PubMed  Google Scholar 

  • Thielitz A, Abdel-Naser MB, Fluhr JW et al (2010) Topical retinoids in acne – an evidence-based overview. Acne Today J Dtsch Dermatol Ges Suppl 1:S15–S23

    Google Scholar 

  • Vahlquist A (2007) Retinoids and the skin: from vitamin A in human epidermis to the pharmacology of oral retinoids in dermatology. In: Vahlquist A, Duvic M (eds) Retinoids and carotenoids in dermatology, 1st edn. Informa Healthcare, New York

    Chapter  Google Scholar 

  • Vahlquist A, Rollmann O, Shroot B (1998) Pharmacokinetics of oral retinoids in clinical practice. In: Lowe N, Marks R (eds) Retinoids. A clinician’s guide, 2nd edn. Martin Dunitz, London

    Google Scholar 

  • Wiegand UW, Chou RC (1998) Pharmacokinetics of acitretin and etretinate. J Am Acad Dermatol 39:25–33

    Article  Google Scholar 

  • Zaenglein AL (2008) Topical retinoids in the treatment of acne vulgaris [Review]. Semin Cutan Med Surg 27:177–182

    Article  PubMed  CAS  Google Scholar 

  • Zhang C, Duvic M (2006) Treatment of cutaneous T-cell lymphoma with retinoids. Dermatol Ther 19:264–267

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Sonja C. Molin .

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© 2012 Springer-Verlag Berlin Heidelberg

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Molin, S.C., Ruzicka, T. (2012). Retinoids. In: Rustemeyer, T., Elsner, P., John, SM., Maibach, H.I. (eds) Kanerva's Occupational Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02035-3_91

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  • DOI: https://doi.org/10.1007/978-3-642-02035-3_91

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02034-6

  • Online ISBN: 978-3-642-02035-3

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