Abstract
Cobalt is a frequent cause of contact allergy, often seen together with allergy to nickel or chromium. Workers in the hardmetal, construction, and electronics industries and dental technicians, among others, are often allergic to cobalt.
The clinical relevance of patch test reactivity to cobalt is often difficult to establish. Scarce knowledge about sources of skin exposure contributes to the difficulties.
Cobalt has broad applications. Cobalt-containing materials such as hardmetals, alloys, coatings, and compounds have different ability to release cobalt ions upon skin contact and to cause dermatitis.
Quantification of cobalt on the skin by wipe sampling, a new spot test for identifying cobalt release, and assessment of cobalt release from materials immersed in artificial sweat, will increase knowledge and facilitate prevention of cobalt allergy.
Cobalt and cobalt compounds cause occupational lung disease and they are classified as probably and possibly carcinogenic, and as toxic to the environment.
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References
Allenby CF, Basketter DA (1989) Minimum eliciting patch test concentrations of cobalt. Contact Dermatitis 20:185–190
Athavale P, Shum KW, Chen Y et al (2007) Occupational dermatitis related to chromium and cobalt: experience of dermatologists (EPIDERM) and occupational physicians (OPRA) in the U.K. over an 11-year period (1993–2004). Br J Dermatol 157:518–522
Basketter DA, Lea LJ, Cooper KJ et al (1999) Identification of metal allergens in the local lymph node assay. Am J Contact Dermat 10:207–212
Basketter DA, Angelini G, Ingber A et al (2003) Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact Dermatitis 49:1–7
Bock M, Schmidt A, Bruckner T et al (2003) Occupational skin disease in the construction industry. Br J Dermatol 149:1165–1171
Burrows D, Adams RM, Flint GN (1999) Metals. In: Adams RM (ed) Occupational skin disease. W.B. Saunders, Philadelphia
Cahill JL, Andersen KE (2010) Occupational cobalt-allergic contact dermatitis resulting from polyester resin. Contact Dermatitis 63:292–294
Carøe C, Andersen KE, Mortz CG (2011) Fluctuations in the prevalence of nickel and cobalt allergy in eczema patients patch tested after implementation of the nickel regulation in Denmark. Contact Dermatitis 64:126–131
Cobalt Facts (2011) Cobalt Development Institute, http://www.thecdi.com/cobaltfacts.php. Accessed 28 Aug 2011
Day GA, Virji MA, Stefaniak AB (2009) Characterization of exposures among cemented tungsten carbide workers. Part II: assessment of surface contamination and skin exposures to cobalt, chromium and nickel. J Expo Sci Environ Epidemiol 19:423–434
de Fine Olivarius F, Menné T (1992) Skin reactivity to metallic cobalt in patients with a positive patch test to cobalt chloride. Contact Dermatitis 27:241–243
Fischer T, Rystedt I (1983) Cobalt allergy in hard metal workers. Contact Dermatitis 9:115–121
Fischer T, Rystedt I (1985) False-positive, follicular and irritant patch test reactions to metal salts. Contact Dermatitis 12:93–98
Geier J, Lessmann H, Schnuch A et al (2004) Contact sensitizations in metalworkers with occupational dermatitis exposed to water-based metalworking fluids: results of the research project “FaSt”. Int Arch Occup Environ Health 77:543–551
Goon AT, Goh CL (2005) Metal allergy in Singapore. Contact Dermatitis 52:130–132
Gruvberger B, Bruze M, Fregert S et al (2011) Allergens exposure assessment. In: Johansen JD, Frosch P, Lepoittevin J-P (eds) Contact Dermatitis, 5th edn. Springer, Berlin
Guo YL, Wang BJ, Yeh KC et al (1999) Dermatoses in cement workers in southern Taiwan. Contact Dermatitis 40:1–7
Irvine C, Pugh CE, Hansen EJ et al (1994) Cement dermatitis in underground workers during construction of the channel tunnel. Occup Med (Lond) 44:17–23
Julander A, Hindsén M, Skare L et al (2009) Cobalt-containing alloys and their ability to release cobalt and cause dermatitis. Contact Dermatitis 60:165–170
Julander A, Skare L, Mulder M et al (2010) Skin deposition of nickel, cobalt, and chromium in production of gas turbines and space propulsion components. Ann Occup Hyg 54:340–350
Kanerva L, Jolanki R, Estlander T et al (2000) Incidence rates of occupational allergic contact dermatitis caused by metals. Am J Contact Dermat 11:155–160
Kligman AM (1966) The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol 47:393–409
Lee JY, Yoo JM, Cho BK et al (2001) Contact dermatitis in Korean dental technicians. Contact Dermatitis 45:13–16
Lidén C, Wahlberg JE (1994) Cross-reactivity to metal compounds studied in guinea pigs induced with chromate or cobalt. Acta Derm Venereol 74:341–343
Lidén C, Skare L, Lind B et al (2006) Assessment of skin exposure to nickel, chromium and cobalt by acid wipe sampling and ICP-MS. Contact Dermatitis 54:233–238
Lidén C, Skare L, Nise G et al (2008a) Deposition of nickel, chromium, and cobalt on the skin in some occupations – assessment by acid wipe sampling. Contact Dermatitis 58:347–354
Lidén C, Skare L, Vahter M (2008b) Release of nickel from coins and deposition onto skin from coin handling–comparing euro coins and SEK. Contact Dermatitis 59:31–37
Lidén C, Bruze M, Thyssen JP et al (2011) Metals. In: Johansen JD, Frosch P, Lepoittevin J-P (eds) Contact dermatitis, 5th edn. Springer, Berlin
Lindberg M, Edman B, Fischer T et al (2007) Time trends in Swedish patch test data from 1992 to 2000. A multi-centre study based on age- and sex-adjusted results of the Swedish standard series. Contact Dermatitis 56:205–210
Linnainmaa M, Kiilunen M (1997) Urinary cobalt as a measure of exposure in the wet sharpening of hard metal and stellite blades. Int Arch Occup Environ Health 69:193–200
Malten KE (1975) Cobalt and chromium in offset printing. Contact Dermatitis 1:120
Pirilä V (1953) Sensitization to cobalt in pottery workers. Acta Derm Venereol 33:193–198
Pirilä V, Geier L (1964) On cobalt allergy among porcelain workers. Hautarzt 15:491–493
Ratcliffe J, English JS (1998) Allergic contact dermatitis from cobalt in animal feed. Contact Dermatitis 39:201–202
Rietschel RL, Fowler JFJ (2008) Metals. In: Rietschel RL, Fowler JFJ (eds) Fisher’s contact dermatitis, 6th edn. BC Decker, Hamilton
Schwartz L, Peck SM, Blair KE et al (1945) Allergic dermatitis due to metallic cobalt. J Allergy Clin Immunol 16:51–53
Shiao JS, Sheu HM, Chen CJ et al (2004) Prevalence and risk factors of occupational hand dermatoses in electronics workers. Toxicol Ind Health 20:1–7
Tandon R, Aarts B (1993) Chromium, nickel and cobalt contents of some Australian cements. Contact Dermatitis 28:201–205
Thyssen JP, Linneberg A, Menné T et al (2007) The epidemiology of contact allergy in the general population–prevalence and main findings. Contact Dermatitis 57:287–299
Thyssen JP, Menné T, Johansen JD et al (2010) A spot test for detection of cobalt release – early experience and findings. Contact Dermatitis 63:63–69
Uter W, Ruhl R, Pfahlberg A et al (2004) Contact allergy in construction workers: results of a multifactorial analysis. Ann Occup Hyg 48:21–27
Uter W, Ramsch C, Aberer W et al (2009) The European baseline series in 10 European Countries, 2005/2006–results of the European Surveillance System on Contact Allergies (ESSCA). Contact Dermatitis 61:31–38
Wahlberg JE, Lidén C (2000) Cross-reactivity patterns of cobalt and nickel studied with repeated open applications (ROATS) to the skin of guinea pigs. Am J Contact Dermat 11:42–48
Zug KA, Warshaw EM, Fowler JF Jr et al (2009) Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis 20:149–160
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Lidén, C., Julander, A. (2012). Cobalt. In: Rustemeyer, T., Elsner, P., John, SM., Maibach, H.I. (eds) Kanerva's Occupational Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02035-3_45
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DOI: https://doi.org/10.1007/978-3-642-02035-3_45
Publisher Name: Springer, Berlin, Heidelberg
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