Abstract
Acute and recurrent vesicular hand dermatitis is a subtype of hand eczema.
This term covers dyshidrotic hand dermatitis (eczema) and pompholyx, terms that should be abandoned.
The disease is characterized by eruptive, vesicular dermatitis reactions that affect the palms, the palmar and lateral aspects of the fingers, and the periungual area.
The vesicles or bullous lesions are often large and deep-seated.
Causes and aggravating factors include emotional stress, hyperhidrosis, weather changes, atopy, mycosis, irritants, contact allergens, and systemic exposure to metals, drugs, and food. However, the cause is often unknown.
Treatment includes primarily removal of causative exposures as well as topical corticosteroids, phototherapy, and in some cases systemic treatment.
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References
Agrup G (1969) Hand eczema and other hand dermatosis in South Sweden. Acta Derm Venereol 49:1–91
Behrens S, von Kobyletzki G, Gruss C, Reuther T, Altmeyer P, Kerscher M (1999) PUVA-bath photochemotherapy (PUVA-soak therapy) of recalcitrant dermatoses of the palms and soles. Photodermatol Photoimmunol Photomed 15:47–51
Belsito DV, Fowler JF Jr, Marks JG Jr, Pariser DM, Hanifin J, Duarte IA, Pires MC, Cruz PD Jr, Langley RG, Patel P, Bush C, Thurston M, Graeber M, Cherill R (2004) Pimecrolimus cream 1%: a potential new treatment for chronic hand dermatitis. Cutis 73:31–38
Benedek T (1974) Pompholyx of the hands and feet. Its etiology, pathogenesis and specific vaccine therapy. (Formerly: ‘epidermophytosis’ of hands and feet). Mycopathol Mycol Appl 53:25–44
Bollag W, Ott F (1999) Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid. Dermatology 199:308–312
Bryld LE, Agner T, Kyvik KO, Brondsted L, Hindsberger C, Menné T (2000) Hand eczema in twins: a questionnaire investigation. Br J Dermatol 142:298–305
Bryld LE, Agner T, Menné T (2003) Relation between vesicular eruptions on the hands and tinea pedis, atopic dermatitis and nickel allergy. Acta Derm Venereol 83:186–188
Castelain PY (1987) Dysidrosis. Ann Dermatol Venereol 114:579–585
Chen JJ, Liang YH, Zhou FS, Yang S, Wang J, Wang PG, Du WH, Xu SJ, Huang W, Zhang XJ (2006) The gene for a rare autosomal dominant form of pompholyx maps to chromosome 18q22.1-18q22.3. J Invest Dermatol 126:300–304
Christensen OB, Lindstrom C, Löfberg H, Möller H (1981) Micromorphology and specificity of orally induced flare-up reactions in nickel-sensitive patients. Acta Derm Venereol 61:505–510
Cox JS (1971) Disodium cromoglycate. Mode of action and its possible relevance to the clinical use of the drug. Br J Dis Chest 65:189–204
Crosti C, Lodi A (1993) Pompholyx: a still unresolved kind of eczema. Dermatology 186:241–242
Davis MD, McEvoy MT, el-Azhary RA (1998) Topical psoralen-ultraviolet A therapy for palmoplantar dermatoses: experience with 35 consecutive patients. Mayo Clin Proc 73:407–411
de Boer EM, Bruynzeel DP, van Ketel WG (1988) Dyshidrotic eczema as an occupational dermatitis in metal workers. Contact Dermatitis 19:184–188
Diepgen TL, Andersen KE, Brandao FM, Bruze M, Bruynzeel DP, Frosch P, Goncalo M, Goossens A, Le Coz CJ, Rustemeyer T, White IR, Agner T (2009) Hand eczema classification: a cross-sectional, multicentre study of the aetiology and morphology of hand eczema. Br J Dermatol 160:353–358
Douwes KE, Karrer S, Abels C, Landthaler M, Szeimies RM (2000) Does smoking influence the efficacy of bath-PUVA therapy in chronic palmoplantar eczema? Photodermatol Photoimmunol Photomed 16:25–29
Edman B (1988) Palmar eczema: a pathogenetic role for acetylsalicylic acid, contraceptives and smoking? Acta Derm Venereol 68:402–407
Egan CA, Rallis TM, Meadows KP, Krueger GG (1999) Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx. J Am Acad Dermatol 40:612–614
Ekelund AG, Möller H (1969) Oral provocation in eczematous contact allergy to neomycin and hydroxy-quinolines. Acta Derm Venereol 49:422–426
Fairris GM, Jones DH, Mack DP, Rowell NR (1985) Conventional superficial X-ray versus Grenz ray therapy in the treatment of constitutional eczema of the hands. Br J Dermatol 112:339–341
Fairris GM, Mack DP, Rowell NR (1984) Superficial X-ray therapy in the treatment of constitutional eczema of the hands. Br J Dermatol 111:445–449
Flood JM, Perry DJ (1946) Recurrent vesicular eruption of the hands due to food allergy. J Invest Dermatol 7:309–327
Granlund H, Erkko P, Eriksson E, Reitamo S (1996) Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema. Acta Derm Venereol 76:371–376
Grattan CE, Carmichael AJ, Shuttleworth GJ, Foulds IS (1991) Comparison of topical PUVA with UVA for chronic vesicular hand eczema. Acta Derm Venereol 71:118–122
Guillet MH, Wierzbicka E, Guillet S, Dagregorio G, Guillet G (2007) A 3-year causative study of pompholyx in 120 patients. Arch Dermatol 143:1504–1508
Hansen O, Kuchler T, Lotz GR, Richter R (1981) Wilckens A [My fingers itch, but my hands are bound. An exploratory psychosomatic study of patients with dyshidrosis of the hands (cheiropompholyx)]. Z Psychosom Med Psychoanal 27:275–290
Iannaccone S, Sferrazza B, Quattrini A, Smirne S, Ferini-Strambi L (1999) Pompholyx (vesicular eczema) after i.v. immunoglobulin therapy for neurologic disease. Neurology 53:1154–1155
Jain VK, Aggarwal K, Passi S, Gupta S (2004) Role of contact allergens in pompholyx. J Dermatol 31:188–193
Jensen CS, Menné T, Johansen JD (2006) Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis. Contact Dermatitis 54:79–86
Jensen CS, Menné T, Lisby S, Kristiansen J, Veien NK (2003) Experimental systemic contact dermatitis from nickel: a dose-response study. Contact Dermatitis 49:124–132
Kaaber K, Menné T, Veien N, Hougaard P (1983) Treatment of nickel dermatitis with Antabuse; a double blind study. Contact Dermatitis 9:297–299
Kaaber K, Veien NK, Tjell JC (1978) Low nickel diet in the treatment of patients with chronic nickel dermatitis. Br J Dermatol 98:197–201
Kellum RE (1973) Dyshidrotic hand eczema: a psychotherapeutic approach. Cutis 16:875–878
King CM, Chalmers RJ (1984) A double-blind study of superficial radiotherapy in chronic palmar eczema. Br J Dermatol 111:451–454
Kodlys KW, Meyer RP (1979) Biofeedback training in the therapy of dyshidrosis. Cutis 24:219–221
Kutzner H, Wurzel RM, Wolff HH (1986) Are acrosyringia involved in the pathogenesis of “dyshidrosis”? Am J Dermatopathol 8:109–116
Lantinga H, Nater JP, Coenraads PJ (1984) Prevalence, incidence and course of eczema on the hands and forearms in a sample of the general population. Contact Dermatitis 10:135–139
Lee WJ, Lee DW, Kim CH, Won CH, Chang SE, Lee MW, Choi JH, Moon KC (2009) Pompholyx with bile-coloured vesicles in a patient with jaundice: are sweat ducts involved in the development of pompholyx? J Eur Acad Dermatol Venereol 24(2):235–236
Lehucher-Michel MP, Koeppel MC, Lanteaume A, Sayag J (2000) Dyshidrotic eczema and occupation: a descriptive study. Contact Dermatitis 43:200–205
Lerbaek A, Kyvik KO, Ravn H, Menné T, Agner T (2007) Incidence of hand eczema in a population-based twin cohort: genetic and environmental risk factors. Br J Dermatol 157:552–557
Lerbaek A, Kyvik KO, Ravn H, Menné T, Agner T (2008) Clinical characteristics and consequences of hand eczema – an 8-year follow-up study of a population-based twin cohort. Contact Dermatitis 58:210–216
LeVine MJ, Parrish JA, Fitzpatrick TB (1981) Oral methoxsalen photochemotherapy (PUVA) of dyshidrotic eczema. Acta Derm Venereol 61:570–571
Lodi A, Betti R, Chiarelli G, Urbani CE, Crosti C (1992) Epidemiological, clinical and allergological observations on pompholyx. Contact Dermatitis 26:17–21
Löfgren SM, Warshaw EM (2006) Dyshidrosis: epidemiology, clinical characteristics, and therapy. Dermatitis 17:165–181
Magina S, Barros MA, Ferreira JA, Mesquita-Guimaraes J (2003) Atopy, nickel sensitivity, occupation, and clinical patterns in different types of hand dermatitis. Am J Contact Dermat 14:63–68
Man I, Ibbotson SH, Ferguson J (2004) Photoinduced pompholyx: a report of 5 cases. J Am Acad Dermatol 50:55–60
Meding B, Alderling M, Albin M, Brisman J, Wrangsjö K (2009) Does tobacco smoking influence the occurrence of hand eczema? Br J Dermatol 160:514–518
Meding B, Swanbeck G (1989) Epidemiology of different types of hand eczema in an industrial city. Acta Derm Venereol 69:227–233
Meneghini CL, Angelini G (1979) Contact and microbial allergy in pompholyx. Contact Dermatitis 5:46–50
Menné T, Hjorth N (1983) Pompholyx-dyshidrotic eczema. Semin Dermatol 2:75–80
Miller RM, Coger RW (1979) Skin conductance conditioning with dyshidrotic eczema patients. Br J Dermatol 101:435–440
Montnemery P, Nihlen U, Lofdahl CG, Nyberg P, Svensson A (2005) Prevalence of hand eczema in an adult Swedish population and the relationship to risk occupation and smoking. Acta Derm Venereol 85:429–432
Nielsen NH, Menné T, Kristiansen J, Christensen JM, Borg L, Poulsen LK (1999) Effects of repeated skin exposure to low nickel concentrations: a model for allergic contact dermatitis to nickel on the hands. Br J Dermatol 141:676–682
Niinimaki A (1995) Double-blind placebo-controlled peroral challenges in patients with delayed-type allergy to balsam of Peru. Contact Dermatitis 33:78–83
Odia S, Vocks E, Rakoski J, Ring J (1996) Successful treatment of dyshidrotic hand eczema using tap water iontophoresis with pulsed direct current. Acta Derm Venereol 76:472–474
Ogden S, Clayton TH, Goodfield MJ (2006) Recalcitrant hand pompholyx: variable response to etanercept. Clin Exp Dermatol 31:145–146
Pearce VJ, Mortimer PS (2009) Hand dermatitis and lymphoedema. Br J Dermatol 161:177–180
Petering H, Breuer C, Herbst R, Kapp A, Werfel T (2004) Comparison of localized high-dose UVA1 irradiation versus topical cream psoralen-UVA for treatment of chronic vesicular dyshidrotic eczema. J Am Acad Dermatol 50:68–72
Petersen CS, Menné T (1992) Cyclosporin A responsive chronic severe vesicular hand eczema. Acta Derm Venereol 72:436–437
Pickenacker A, Luger TA, Schwarz T (1998) Dyshidrotic eczema treated with mycophenolate mofetil. Arch Dermatol 134:378–379
Pitche P, Boukari M, Tchangai-Walla K (2006) Factors associated with palmoplantar or plantar pompholyx: a case-control study. Ann Dermatol Venereol 133:139–143
Polderman MC, Govaert JC, le CS, Pavel S (2003) A double-blind placebo-controlled trial of UVA-1 in the treatment of dyshidrotic eczema. Clin Exp Dermatol 28:584–587
Rosen K, Mobacken H, Swanbeck G (1987) Chronic eczematous dermatitis of the hands: a comparison of PUVA and UVB treatment. Acta Derm Venereol 67:48–54
Ruzicka T, Larsen FG, Galewicz D, Horvath A, Coenraads PJ, Thestrup-Pedersen K, Ortonne JP, Zouboulis CC, Harsch M, Brown TC, Zultak M (2004) Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol 140:1453–1459
Ruzicka T, Lynde CW, Jemec GB, Diepgen T, Berth-Jones J, Coenraads PJ, Kaszuba A, Bissonnette R, Varjonen E, Hollo P, Cambazard F, Lahfa M, Elsner P, Nyberg F, Svensson A, Brown TC, Harsch M, Maares J (2008) Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol 158:808–817
Scerri L (1999) Azathioprine in dermatological practice. An overview with special emphasis on its use in non-bullous inflammatory dermatoses. Adv Exp Med Biol 455:343–348
Schempp CM, Muller H, Czech W, Schopf E, Simon JC (1997) Treatment of chronic palmoplantar eczema with local bath-PUVA therapy. J Am Acad Dermatol 36:733–737
Schiener R, Gottlober P, Muller B, Williams S, Pillekamp H, Peter RU, Kerscher M (2005) PUVA-gel vs. PUVA-bath therapy for severe recalcitrant palmoplantar dermatoses. A randomized, single-blinded prospective study. Photodermatol Photoimmunol Photomed 21:62–67
Schnopp C, Remling R, Mohrenschlager M, Weigl L, Ring J, Abeck D (2002) Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial. J Am Acad Dermatol 46:73–77
Schurmeyer-Horst F, Luger TA, Bohm M (2007) Long-term efficacy of occlusive therapy with topical pimecrolimus in severe dyshidrosiform hand and foot eczema. Dermatology 214:99–100
Semhoun-Ducloux S, Ducloux D, Miguet JP (2000) Mycophenolate mofetil-induced dyshidrotic eczema. Ann Intern Med 132:417
Sezer E, Etikan I (2007) Local narrowband UVB phototherapy vs. local PUVA in the treatment of chronic hand eczema. Photodermatol Photoimmunol Photomed 23:10–14
Staerkjaer L, Menné T (1990) Nickel allergy and orthodontic treatment. Eur J Orthod 12:284–289
Stambaugh MD, DeNittis AS, Wallner PE, Heymann WR (2000) Complete remission of refractory dyshidrotic eczema with the use of radiation therapy. Cutis 65:211–214
Stojanovic D, Nikic D, Lazarevic K (2004) The level of nickel in smoker’s blood and urine. Cent Eur J Public Health 12:187–189
Stuckert J, Nedorost S (2008) Low-cobalt diet for dyshidrotic eczema patients. Contact Dermatitis 59:361–365
Swartling C, Naver H, Lindberg M, Anveden I (2002) Treatment of dyshidrotic hand dermatitis with intradermal botulinum toxin. J Am Acad Dermatol 47:667–671
Thelin I, Agrup G (1985) Pompholyx–a one year series. Acta Derm Venereol 65:214–217
Thyssen JP, Maibach HI (2008) Drug-elicited systemic allergic (contact) dermatitis–update and possible pathomechanisms. Contact Dermatitis 59:195–202
Veien N, Menné T (2000) Acute and recurrent vesicular hand dermatitis (pompholyx). In: Menné T, Maibach H (eds) Hand eczema. CRC Press, Boca Raton, pp 147–164
Veien NK (2009) Acute and recurrent vesicular hand dermatitis. Dermatol Clin 27:337–353, vii
Veien NK, Hattel T, Justesen O, Nørholm A (1983) Oral challenge with metal salts. (I). Vesicular patch-test-negative hand eczema. Contact Dermatitis 9:402–406
Veien NK, Hattel T, Justesen O, Nørholm A (1987) Oral challenge with nickel and cobalt in patients with positive patch tests to nickel and/or cobalt. Acta Derm Venereol 67:321–325
Veien NK, Hattel T, Laurberg G (1994) Chromate-allergic patients challenged orally with potassium dichromate. Contact Dermatitis 31:137–139
Veien NK, Hattel T, Laurberg G (1995) Placebo-controlled oral challenge with cobalt in patients with positive patch tests to cobalt. Contact Dermatitis 33:54–55
Veien NK, Hattel T, Laurberg G (1996) Can oral challenge with balsam of Peru predict possible benefit from a low-balsam diet? Am J Contact Dermat 7:84–87
Veien NK, Hattel T, Laurberg G (2008) Hand eczema: causes, course, and prognosis I. Contact Dermatitis 58:330–334
Veien NK, Kaaber K (1979) Nickel, cobalt and chromium sensitivity in patients with pompholyx (dyshidrotic eczema). Contact Dermatitis 5:371–374
Veien NK, Ølholm LP, Thestrup-Pedersen K, Schou G (1999) Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol 140:882–886
Vocks E, Plotz SG, Ring J (1999) The dyshidrotic eczema area and severity index – a score developed for the assessment of dyshidrotic eczema. Dermatology 198:265–269
Volden G (1992) Successful treatment of chronic skin diseases with clobetasol propionate and a hydrocolloid occlusive dressing. Acta Derm Venereol 72:69–71
Wollina U (2008) Pompholyx: what’s new? Expert Opin Investig Drugs 17:897–904
Wollina U, Karamfilov T (2002) Adjuvant botulinum toxin A in dyshidrotic hand eczema: a controlled prospective pilot study with left–right comparison. J Eur Acad Dermatol Venereol 16:40–42
Yokozeki H, Katayama I, Nishioka K, Kinoshita M, Nishiyama S (1992) The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx. J Dermatol 19:964–967
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Thyssen, J.P., Menné, T. (2012). Acute and Recurrent Vesicular Hand Dermatitis. In: Rustemeyer, T., Elsner, P., John, SM., Maibach, H.I. (eds) Kanerva's Occupational Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02035-3_18
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