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Vasopressin

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Synonyms

Antidiuretic hormone (ADH); Arginine vasopressin (AVP); Argipressin

Trade Names

  • Pitressin Link Pharmaceuticals, Parke-Davis, JHP Pharmaceuticals

  • Pressyn Ferring

  • Vasopressin APP Pharmaceuticals, Watson Laboratories

Class and Category

Vasopressin is an endogenous peptide hormone produced as part of a pro-hormone (preprovasopressin) in the paraventricular and supraoptic nuclei of the hypothalamus [1, 2]. From here it is transported via axonal transport to the posterior pituitary gland where it is stored in Herring bodies within nerve terminals (Fig. 1). The major stimuli for release into the circulation include the following:

  1. (a)

    Decreased circulating blood volume (e.g., in hypovolemic shock) through baro-receptors in the left atrium, aortic arch, and carotid sinus

    Vasopressin. Figure 1
    figure 1_331 figure 1_331

    The major actions of vasopressin in restoring blood volume and blood pressure

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References

  1. Vincent JL, Su F (2008) Physiology and pathophysiology of the vasopressinergic system. Best Pract Res Clin Anaesthesiol 22:243–252

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  2. Maybauer MO, Maybauer DM, Enkhbaatar P, Traber DL (2008) Physiology of the vasopressin receptors. Best Pract Res Clin Anaesthesiol 22:253–263

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  3. Wenzel V, Raab H, Dünser MW (2008) Role of arginine varopressin in the setting of cardiopulmonary resuscitation. Best Pract Res Clin Anaesthesiol 22:287–297

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  4. Gueugiaud PY, David J-S, Chanzy E, Hubert H et al (2008) Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation. N Engl J Med 359:21–30

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  5. Russell JA, Walley KR, Singer J, Gordon AC et al (2008) Vasopressin versus Norepinephrine infusion in patients with septic shock. N Engl J Med 358:877–887

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  6. Russell JA (2007) Vasopressin in septic shock. Crit Care Med 35:S609–S615

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Correspondence to Rinaldo Bellomo M.D. .

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© 2012 Springer-Verlag Berlin Heidelberg

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Jones, D., Bellomo, R. (2012). Vasopressin. In: Vincent, JL., Hall, J.B. (eds) Encyclopedia of Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00418-6_331

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  • DOI: https://doi.org/10.1007/978-3-642-00418-6_331

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-00417-9

  • Online ISBN: 978-3-642-00418-6

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