Skip to main content
SpringerLink
Log in

Melanoma and Skin Aging

  • Reference work entry
Textbook of Aging Skin

Abstract

The interaction between skin aging and melanoma derive from the contributions of chronologic aging and photoaging, and the subsequent changes that occur in each scenario in the skin. The resultant changes in skin dynamics and their impact on melanoma development and progression are the focus of this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 499.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. American Cancer Society. (2009) Cancer Facts and Figures 2009. http://www.cancer.org/docroot/STT/STT_0.asp

  2. Heenan PJ, English DR, Holman CDJ, Armstrong BK. Survival among patients with clinical stage I cutaneous malignant melanoma diagnosed in Western Australia in 1975–1976 and 1980/1981. Cancer. 1991;68:2079–2087.

    CAS  PubMed  Google Scholar 

  3. Rosso S, Sera F, Segnan N, Zanetti R. Sun exposure prior to diagnosis is associated with improved survival in melanoma patients: Results from a long-term follow-up study of Italian patients. Eur J Cancer. 2008;44:1275–1281.

    PubMed  Google Scholar 

  4. Breslow A. Thickness, cross-sectional area, and depth of invasion in the prognosis of cutaneous melanoma. Am Surg. 1970;66:527–531.

    Google Scholar 

  5. Finley JW, Rodriguez LM, Letourneau R, Driscoll D, Kraybill W. Pathologic and clinical features influencing outcome of thin cutaneous melanoma: correlation with newly proposed staging system. Am Surg. 2000;66:527–531.

    CAS  PubMed  Google Scholar 

  6. Buzaid CM, Ross MI, Balch CM, et al. Critical analysis of the current American Joint Committee on Cancer staging system for cutaneous melanoma and proposal of a new staging system. J Clin Oncol. 1997;15:1039–1051.

    CAS  PubMed  Google Scholar 

  7. Balch CM. Cutaneous melanoma: prognosis and treatment results worldwide. Semin Surg Oncol. 1992;8:400–414.

    CAS  PubMed  Google Scholar 

  8. Gershenwald JE, Thompson W, Mansfield PF, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol. 1999;17:976–983.

    CAS  PubMed  Google Scholar 

  9. Volmer RT. Solar elastosis in cutaneous melanoma. Am J Clin Pathol. 2007;128:260–264.

    Google Scholar 

  10. Lachiewicz AM, Berwick M, Wiggins CL, Thomas NE. Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program. Arch Dermatol. 2008;144:515–521.

    PubMed  Google Scholar 

  11. Desai A, Krathen R, Orengo I, Medrano EE. The age of skin cancers. Sci Aging Knowl Environ. 2006;9:pe13.

    Google Scholar 

  12. Geller AC, Miller DR, Annas GD, et al. Melanoma incidence and mortality among US whites, 1969–1999. JAMA. 2002;288:1719–1720.

    PubMed  Google Scholar 

  13. Yaar M, Gilchrest BA. Ageing and photoageing of keratinocytes and melanocytes. Clin Exp Dermatol. 2001;26:583–591.

    CAS  PubMed  Google Scholar 

  14. Sweeter SM, Geller AC, Kirkwood JM. Melanoma in the older person. Oncology. 2004;18:1187–1196.

    Google Scholar 

  15. Schafer T, Merkl J, Klemm E, Wichmann HE, Ring J, KORA study group. The epidemiology of nevi and signs of skin aging in the adult general population: results of the KORA-survey 2000. J Invest Dermatol. 2006;126:1490–1496.

    PubMed  Google Scholar 

  16. Sage J. Making young tumors old: a new weapon against cancer? Sci Aging Knowl Environ. 2005;33:pe25.

    Google Scholar 

  17. Lachiewicz AM, Berwick M, Wiggins CL, Thomas NE. Epidemiologic support for melanoma heterogeneity using the Surveillance, Epidemiology, and End Results program. J Invest Dermatol. 2008;128:243–245.

    CAS  PubMed  Google Scholar 

  18. Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK, Green AC. Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma. J Natl Cancer Inst. 2003;95:806–812.

    PubMed  Google Scholar 

  19. Austin PF, Cruse CW, Lyman G, Schroer K, Glass F, Reintgen DS. Age as a prognostic factor in the malignant melanoma population. Ann Surg Oncol. 1994;1:487–494.

    CAS  PubMed  Google Scholar 

  20. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer Melanoma Staging System. J Clin Oncol. 2001;19:3622–3634.

    CAS  PubMed  Google Scholar 

  21. Reyes-Ortiz CA, Goodwin JS, Freeman JL, Kou YF. Socioeconomic status and survival in older patients with melanoma. JAGS. 2006;54:1758–1764.

    Google Scholar 

  22. Syrigos KN, Tzannou I, Katirtzoglou N, Georgiou E. Skin cancer in the elderly. In Vivo. 2005;19:643–652.

    PubMed  Google Scholar 

  23. Kaplan RP. The aging skin. Comp Ther. 1991;17:59–67.

    CAS  Google Scholar 

  24. Moriwaki SI, Ray S, Tarone RE, Kraemer KH, Grossman L. The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability. Mutat Res. 1996;364:117–123.

    PubMed  Google Scholar 

  25. Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L. DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. Proc Natl Acad Sci USA. 1993;90:1614–1618.

    CAS  PubMed  Google Scholar 

  26. Yamada M, Udono MU, Hori M, Hirose R, Sato S, Mori T, Nikaido O. Aged human skin removes UVB-induced pyrimidine dimmers from the epidermis more slowly than younger adult skin in vivo. Arch Dermatol Res. 2006;297:294–302.

    PubMed  Google Scholar 

  27. Uitto J. The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. J Drugs Dermatol. 2008;12–16.

    Google Scholar 

  28. Rabe JH, Mamelak AJ, McElgunn PJS, Morison WL, Sauder DN. Photoaging: mechanisms and repair. J Am Acad Dermatol. 2006;55:1–19.

    PubMed  Google Scholar 

  29. Sunderkotter C, Kalden H, Luger TA. Aging and the skin immune system. Arch Dermatol. 1997;133:1256–1262.

    CAS  PubMed  Google Scholar 

  30. Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kircker A, Barnhill RL. Sun exposure and mortality from melanoma. J Natl Cancer Inst. 2005;97:1–5.

    Google Scholar 

  31. Gaudy-Marqueste C, Madjlessi N, Guillot B, Avril MF, Grob JJ. Risk factors in elderly people for lentigo maligna compared with other melanomas. Arch Dermatol. 2009;145:418–423.

    PubMed  Google Scholar 

  32. Monestier S, Gaudy C, Gouvernet J, Richard MA, Grob JJ. Multiple senile lentigos of the face, a skin ageing pattern resulting from a life excess of intermittent sun exposure in dark-skinned Caucasians: a case-control study. Br J Dermatol. 2006;154:438–444.

    CAS  PubMed  Google Scholar 

  33. Bradford, PT, Goldstein AM, McMaster ML, Tucker MA. Acral lentiginous melanoma incidence and survival patterns in the United States, 1986–2005. Arch Dermatol. 2009;145:427–434.

    PubMed  Google Scholar 

  34. Golger A, Young DS, Ghazarian D, Neligan PC. Epidemiologic features and prognostic factors of cutaneous head and neck melanoma. Arch Otolaryngol Head Neck Surg. 2007;133:442–447.

    PubMed  Google Scholar 

  35. Landi, et al. MC1R Germline Variants Confer Risk for BRAF-Mutant Melanoma. Science 28: Supporting Online Material, 2006. http://www.sciencemag.org/cgi/content/full/1127515/DC1

Download references

Author information

Authors and Affiliations

  1. Internal Medicine, Division of Epidemiology, University of New Mexico, Albuquerque, New Mexico

    Salina M. Torres & Marianne Berwick

Authors
  1. Salina M. Torres
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marianne Berwick
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Torres, S.M., Berwick, M. (2010). Melanoma and Skin Aging. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_57

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-89656-2_57

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation