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Neoplastic Skin Lesions in the Elderly Patient

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Textbook of Aging Skin

Abstract

As the proportion of the aged in the US population increases, so does the burden of cutaneous disease [1]. Cutaneous diseases of the elderly represent significant morbidity, with many patients having multiple conditions [2]. Hyperproliferative disorders of the skin are strongly associated with exposure to solar radiation and are commonly present in older adults [3]. Although nonmalignant growths are far more common than malignant ones, skin cancers represent about 6% of all dermatology visits [4]. The prevalence of cutaneous malignancies increases with age [5] (Table 55.1 ).

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References

  1. Liao YH, Chen KH, Tseng MP, et al. Pattern of skin diseases in a geriatric patient group in Taiwan: a 7-year survey from the outpatient clinic of a university medical center. Dermatology (Basel). 2001;203:308–313.

    CAS  Google Scholar 

  2. Kligman AM, Koblenzer C. Demographics and psychological implications for the aging population. Dermatol Clin. 1997;15:549–553.

    CAS  PubMed  Google Scholar 

  3. Fenske NA, Lober CW. Structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986;15:571–585.

    CAS  PubMed  Google Scholar 

  4. Bergfeld WF. The aging skin. Int J Fertil Womens Med. 1997;42:57–66.

    CAS  PubMed  Google Scholar 

  5. Harvell JD, Maibach HI. Percutaneous absorption and inflammation in aged skin: a review. J Am Acad Dermatol. 1994;31:1015–1021.

    CAS  PubMed  Google Scholar 

  6. Webster GF. Common skin disorders in the elderly. Clin Cornerstone. 2001;4:39–44.

    CAS  PubMed  Google Scholar 

  7. Armstrong BK, Kricker A. How much melanoma is caused by sun exposure? Melanoma Res. 1993;3:395–401.

    CAS  PubMed  Google Scholar 

  8. Christenson LJ, Borrowman TA, Vachon CM, et al. Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. JAMA. 2005;294:681–690.

    CAS  PubMed  Google Scholar 

  9. Gilchrest B, Krutmann J (eds). Skin Aging. New York: Springer, 2006.

    Google Scholar 

  10. Rass K, Reichrath J. Damage and DNA repair in malignant melanoma and nonmelanoma skin cancer. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  11. de Gruijl FR, Van der Leun JC. Estimate of the wavelength dependency of ultraviolet carcinogenesis in humans and its relevance to the risk assessment of a stratospheric ozone depletion. Health Phys. 1994;67:319–325.

    CAS  PubMed  Google Scholar 

  12. Fields KA. Skin breakthroughs in the year 2000. Int J Fertil Womens Med. 2000;45:175–181.

    CAS  PubMed  Google Scholar 

  13. Rees JL. The genetics of sun sensitivity in humans. Am J Hum Genet. 2004;75:739–751.

    CAS  PubMed  Google Scholar 

  14. Carless M, Griffiths L. Cytogenetics of melanoma and nonmelanoma skin cancer. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  15. Sarasin A. The molecular pathways of ultraviolet-induced carcinogenesis. Mutat Res. 1999;428:5–10.

    CAS  PubMed  Google Scholar 

  16. Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol. 2004;195:298–308.

    CAS  PubMed  Google Scholar 

  17. Emri G, Wenczl E, Van Erp P, et al. Low doses of UVB or UVA induce chromosomal aberrations in cultured human skin cells. J Invest Dermatol. 2000;115:435–440.

    CAS  PubMed  Google Scholar 

  18. Domingo DS, Baron DB. Melanoma and nonmelanoma skin cancers and the immune system. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  19. Erb P, Ji J, Kump E, Mielgo A, Wernli M. Need chapter title. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  20. Donehower LA, Bradley A. The tumor suppressor p53. Biochim Biophys Acta. 1993;1155:181–205.

    CAS  PubMed  Google Scholar 

  21. Letier UGC. Epidemiology of melanoma and nonmelanoma skin cancer – the role of sunlight. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  22. Filipowicz E, Adegboyega P, Sanchez RL, et al. Expression of CD95 (Fas) in sun-exposed human skin and cutaneous carcinomas. Cancer. 2002;94:814–819.

    CAS  PubMed  Google Scholar 

  23. Heckmann M, Zogelmeier F, Konz B. Frequency of facial basal cell carcinoma does not correlate with site-specific UV exposure. Arch Dermatol. 2002;138:1494–1497.

    PubMed  Google Scholar 

  24. Auborn KJ. Carcinogenesis: current trends in skin cancer research. In: Zhai H, Wilhelm KP, Miabach H (eds) Marzulli and Maibach’s Dermatotoxicology. Boca Raton: CRC Press LLC, 2008.

    Google Scholar 

  25. Heywood LA, Burke JF. Mismatch repair in mammalian cells. Bioessays. 1990;12:473–477.

    CAS  PubMed  Google Scholar 

  26. Peltomäki P, Aaltonen LA, Sistonen P, et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science. 1993;260:810–812.

    PubMed  Google Scholar 

  27. Jaax S, Scott LW, Wolf JEJ, et al. General guidelines for a low-fat diet effective in the management and prevention of nonmelanoma skin cancer. Nutr Cancer. 1997;27:150–156.

    CAS  PubMed  Google Scholar 

  28. Lamberg L. Diet may affect skin cancer prevention. JAMA. 1998;279:1427–1428.

    CAS  PubMed  Google Scholar 

  29. Davies TW, Treasure FP, Welch AA, et al. Diet and basal cell skin cancer: results from the EPIC-Norfolk cohort. Br J Dermatol. 2002;146:1017–1022.

    CAS  PubMed  Google Scholar 

  30. Clark LC, Combs GFJ, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996;276:1957–1963.

    CAS  PubMed  Google Scholar 

  31. Biliris KA, Koumantakis E, Dokianakis DN, et al. Human papillomavirus infection of non-melanoma skin cancers in immunocompetent hosts. Cancer Lett. 2000;161:83–88.

    CAS  PubMed  Google Scholar 

  32. Bleiker TO, Graham-Brown RA. Diagnosing skin disease in the elderly. Practitioner. 2000;244:974–981.

    CAS  PubMed  Google Scholar 

  33. Carter DM, Balin AK. Dermatological aspects of aging. Med Clin North Am. 1983;67:531–543.

    CAS  PubMed  Google Scholar 

  34. Shelley WB, Shelley ED. The ten major problems of aging skin. Geriatrics. 1982;37:107–113.

    CAS  PubMed  Google Scholar 

  35. van der Pols JC, Williams GM, Pandeya N, et al. Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer Epidemiol Biomarkers Prev. 2006;15:2546–2548.

    Google Scholar 

  36. Kleinsmith DM, Perricone NV. Common skin problems in the elderly. Dermatol Clin. 1986;4:485–499.

    CAS  PubMed  Google Scholar 

  37. Lin AN, Carter DM, Balin AK. Nonmelanoma skin cancers in the elderly. Clin Geriatr Med. 1989;5:161–170.

    CAS  PubMed  Google Scholar 

  38. Keller KL, Fenske NA, Glass LF. Cancer of the skin in the older patient. Clin Geriatr Med. 1997;13:339–361.

    CAS  PubMed  Google Scholar 

  39. Bickle K, Roark TR, Hsu S. Autoimmune bullous dermatoses: a review. Am Fam Physician. 2002;65:1861–1870.

    PubMed  Google Scholar 

  40. Chia A, Moreno G, Lim A, et al. Actinic keratoses. Aust Fam Physician. 2007;36:539–543.

    PubMed  Google Scholar 

  41. Kelly R. Dermatoses in geriatric patients. Aust Fam Physician. 1977;6:36, 38–41, 43–4, Passim.

    CAS  PubMed  Google Scholar 

  42. Cole HNJ. Skin tumors in the elderly. Postgrad Med. 1968;43:188–191.

    PubMed  Google Scholar 

  43. Lynch PJ. Tumors of the skin. Premalignment and malignant. Minn Med. 1974;57:780–787.

    CAS  PubMed  Google Scholar 

  44. Knox JM, Freeman RG. Diagnosis and treatment of skin tumors in the AGED. Geriatrics. 1967;22:143–155.

    CAS  PubMed  Google Scholar 

  45. Ericson MB, Wennberg A, Larkö O. Review of photodynamic therapy in actinic keratosis and basal cell carcinoma. Ther Clin Risk Manag. 2008;4:1–9.

    CAS  PubMed  Google Scholar 

  46. Pollack SV. Skin cancer in the elderly. Clin Geriatr Med. 1987;3:715–728.

    CAS  PubMed  Google Scholar 

  47. Tschen EH, Wong DS, Pariser DM, et al. Photodynamic therapy using aminolaevulinic acid for patients with nonhyperkeratotic actinic keratoses of the face and scalp: phase IV multicentre clinical trial with 12-month follow up. Br J Dermatol. 2006;155:1262–1269.

    CAS  PubMed  Google Scholar 

  48. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology. 2005–2007.

    Google Scholar 

  49. Epstein E. Does intermittent “pulse” topical 5-fluorouracil therapy allow destruction of actinic keratoses without significant inflammation? J Am Acad Dermatol.1998;38:77–80.

    CAS  PubMed  Google Scholar 

  50. Urbach F. Ultraviolet radiation and skin cancer. In: Smith K (ed) Topics in Photomedicine. Philadelphia: Plenum Press, 1984.

    Google Scholar 

  51. Gordon DSH. Worldwide epidemiology of pre-malignant and malignant cutaneous lesions. In: Andrade R (ed) Cancer of the Skin. Philadelphia: WB Saunders, 1976.

    Google Scholar 

  52. Hill D. Efficacy of sunscreens in protection against skin cancer. Lancet. 1999;354:699–700.

    CAS  PubMed  Google Scholar 

  53. Ananthaswamy HN, Ullrich SE, Mascotto RE, et al. Inhibition of solar simulator-induced p53 mutations and protection against skin cancer development in mice by sunscreens. J Invest Dermatol. 1999;112:763–768.

    CAS  PubMed  Google Scholar 

  54. Shuster S. Is sun exposure a major cause of melanoma? BMJ. 2008;337:a764.

    PubMed  Google Scholar 

  55. Mogensen M, Jemec GBE. Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies. Dermatol Surg. 2007;33:1158–1174.

    CAS  PubMed  Google Scholar 

  56. Gohara MA. Skin cancer in skins of color. J Drugs Dermatol. 2008;7:441–445.

    PubMed  Google Scholar 

  57. Helm K, Findeis-Hosey J. Immunohistochemistry of pigmented actinic keratoses, actinic keratoses, melanomas in situ and solar lentigines with Melan-A. J Cutan Pathol. 2008; 35:931–934.

    PubMed  Google Scholar 

  58. Cheretis C, Angelidou E, Dietrich F, et al. Prognostic value of computer-assisted morphological and morphometrical analysis for detecting the recurrence tendency of basal cell carcinoma. Med Sci Monit. 2008;14:MT13–19.

    PubMed  Google Scholar 

  59. Peris K, Micantonio T, Piccolo D, et al. Dermoscopic features of actinic keratosis. J Dtsch Dermatol Ges. 2007;5:970–976.

    PubMed  Google Scholar 

  60. Eggermont AMM, Voit C. Management of melanoma: a European perspective. Surg Oncol Clin N Am. 2008;17:635–48, x.

    PubMed  Google Scholar 

  61. von Roenn JH, Kheir SM, Wolter JM, et al. Significance of DNA abnormalities in primary malignant melanoma and nevi, a retrospective flow cytometric study. Cancer Res. 1986;46:3192–3195.

    CAS  PubMed  Google Scholar 

  62. Bikle DD. Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism. J Invest Dermatol. 2008;128:2357–2361.

    CAS  PubMed  Google Scholar 

  63. Shea CR, McNutt NS, Volkenandt M, et al. Overexpression of p53 protein in basal cell carcinomas of human skin. Am J Pathol. 1992;141:25–29.

    CAS  PubMed  Google Scholar 

  64. Amstad PA, Cerutti PA. Ultraviolet-B-light-induced mutagenesis of C-H-ras codons 11 and 12 in human skin fibroblasts. Int J Cancer. 1995;63:136–139.

    CAS  PubMed  Google Scholar 

  65. Urabe A, Nakayama J, Taniguchi S, et al. Expression of the fos oncogene in basal cell carcinoma. J Dermatol Sci. 1994;8:50–53.

    CAS  PubMed  Google Scholar 

  66. Eshkoor SA, Ismail P, Rahman SA, et al. p16 Gene expression in basal cell carcinoma. Arch Med Res. 2008;39:668–673.

    CAS  PubMed  Google Scholar 

  67. Kim J, Modlin RL, Moy RL, et al. IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J Immunol. 1995;155:2240–2247.

    CAS  PubMed  Google Scholar 

  68. Goslen JB, Bauer EA. Basal cell carcinoma and collagenase. J Dermatol Surg Oncol. 1986;12:812–817.

    CAS  PubMed  Google Scholar 

  69. Lear JT, Smith AG. Basal cell carcinoma. Postgrad Med J. 1997;73:538–542.

    CAS  PubMed  Google Scholar 

  70. Roewert-Huber J, Lange-Asschenfeldt B, Stockfleth E, et al. Epidemiology and aetiology of basal cell carcinoma. Br J Dermatol. 2007;157(2):47–51.

    CAS  PubMed  Google Scholar 

  71. Tierney L, McPhee S, Papadakis M. Current Medical Diagnosis and Ttreatment. New York: McGraw Hill, 2000.

    Google Scholar 

  72. Stamp GW, Pignatelli M. Distribution of beta 1, alpha 1, alpha 2 and alpha 3 integrin chains in basal cell carcinomas. J Pathol. 1991;163:307–313.

    CAS  PubMed  Google Scholar 

  73. Green A, Williams G, Neale R, et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet. 1999;354:723–729.

    CAS  PubMed  Google Scholar 

  74. Brash DE, Ziegler A, Jonason AS, et al. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Investig Dermatol Symp Proc. 1996;1:136–142.

    CAS  PubMed  Google Scholar 

  75. Erbagci Z, Erkiliç S. Can smoking and/or occupational UV exposure have any role in the development of the morpheaform basal cell carcinoma? A critical role for peritumoral mast cells. Int J Dermatol. 2002;41:275–278.

    PubMed  Google Scholar 

  76. Newman MD, Weinberg JM. Topical therapy in the treatment of actinic keratosis and basal cell carcinoma. Cutis. 2007;79:18–28.

    PubMed  Google Scholar 

  77. Thissen MRTM, Kuijpers DIM, Krekels GAM. Local immune modulator (imiquimod 5% cream) as adjuvant treatment after incomplete Mohs micrographic surgery for large, mixed type basal cell carcinoma: a report of 3 cases. J Drugs Dermatol. 2006;5:461–464.

    CAS  PubMed  Google Scholar 

  78. Wu JK, Oh C, Strutton G, et al. An open-label, pilot study examining the efficacy of curettage followed by imiquimod 5% cream for the treatment of primary nodular basal cell carcinoma. Australas J Dermatol. 2006;47:46–48.

    PubMed  Google Scholar 

  79. Spencer JM. Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma. Dermatol Surg. 2006;32:63–69.

    CAS  PubMed  Google Scholar 

  80. Szeimies R, Gerritsen MP, Gupta G, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol. 2004;51:547–555.

    PubMed  Google Scholar 

  81. Kennedy C, Bajdik CD, Willemze R, et al. The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer. J Invest Dermatol. 2003;120:1087–1093.

    CAS  PubMed  Google Scholar 

  82. Garrett AB. Skin cancer in people of color. In: Snow N, Mikhail GR (eds) Mohs Micrographic Surgery. Madison: University of Wisconsion Press, 2004.

    Google Scholar 

  83. Mueller CS, Reichrath J. Histology of melanoma and nonmelanoma skin cancer. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  84. Akhdari N, Amal S, Ettalbi S. Bowen disease. CMAJ. 2006;175:739.

    PubMed  Google Scholar 

  85. Kossard S, Tan K, Choy C. Keratoacanthoma and infundibulocystic squamous cell carcinoma. Am J Dermatopathol. 2008;30:127–134.

    PubMed  Google Scholar 

  86. Gallagher RP. Sunscreens in melanoma and skin cancer prevention. CMAJ. 2005;173:244–245.

    PubMed  Google Scholar 

  87. American Academy of Dermatology: Bullous Disease http://www.aad.org/public/Publications/pamphlets/bullous.htm. cited December 29, 2008.

  88. Giles GG, Armstrong BK, Burton RC, et al. Has mortality from melanoma stopped rising in Australia? Analysis of trends between 1931 and 1994. BMJ. 1996;312:1121–1125.

    CAS  PubMed  Google Scholar 

  89. McCartney RA. Malignant Melanoma In: Gale Encyclopedia of Cancer. Farmington Hills: Thomson Gale Publishing, 2002.

    Google Scholar 

  90. Beers MH, Berkow BR. Dermatologic disorders: malignant tumors. In: Beers MH, Berkow R (eds) The Merck Manual of Diagnosis and Therapy. Whitehouse Station: Merck Research Laboratories, 2002.

    Google Scholar 

  91. Rass K, Tilgen W. Treatment of melanoma and nonmelanoma skin cancer. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  92. Gillgren P, Brattström G, Frisell J, et al. Effect of primary site on prognosis in patients with cutaneous malignant melanoma. A study using a new model to analyse anatomical locations. Melanoma Res. 2005;15:125–132.

    PubMed  Google Scholar 

  93. Cochran AJ, Elashoff D, Morton DL, et al. Individualized prognosis for melanoma patients. Hum Pathol. 2000;31:327–331.

    CAS  PubMed  Google Scholar 

  94. Moan J, Porojnicu A, Dahlback A. Ultraviolet radiation and malignant melanoma. In: Reicharth J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Biosciences, 2008.

    Google Scholar 

  95. Armstrong BK, Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B. 2001;63:8–18.

    CAS  PubMed  Google Scholar 

  96. Tsao H, Sober AJ. Ultraviolet radiation and malignant melanoma. Clin Dermatol. 1998;16:67–73.

    CAS  PubMed  Google Scholar 

  97. Kraemer KH, Lee MM, Andrews AD, et al. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol. 1994;130:1018–1021.

    CAS  PubMed  Google Scholar 

  98. Hussein MR. Ultraviolet radiation and skin cancer: molecular mechanisms. J Cutan Pathol. 2005;32:191–205.

    PubMed  Google Scholar 

  99. Armstrong BK, Kricker A. Skin cancer. Dermatol Clin. 1995;13:583–594.

    CAS  PubMed  Google Scholar 

  100. Le Marchand L, Saltzman BS, Hankin JH, et al. Sun exposure, diet, and melanoma in Hawaii Caucasians. Am J Epidemiol. 2006;164:232–245.

    PubMed  Google Scholar 

  101. Crombie IK. Variation of melanoma incidence with latitude in North America and Europe. Br J Cancer. 1979;40:774–781.

    CAS  PubMed  Google Scholar 

  102. Gallagher RP, Spinelli JJ, Lee TK. Tanning beds, sunlamps, and risk of cutaneous malignant melanoma. Cancer Epidemiol Biomarkers Prev. 2005;14:562–566.

    Google Scholar 

  103. Setlow RB, Woodhead AD, Grist E. Animal model for ultraviolet radiation-induced melanoma: platyfish-swordtail hybrid. Proc Natl Acad Sci USA. 1989;86:8922–8926.

    CAS  PubMed  Google Scholar 

  104. Menzies SW. Is sun exposure a major cause of melanoma? Yes. BMJ. 2008;337:a763.

    Google Scholar 

  105. Garland CF, Garland FC, Gorham ED. Rising trends in melanoma. An hypothesis concerning sunscreen effectiveness. Ann Epidemiol. 1993;3:103–110.

    CAS  PubMed  Google Scholar 

  106. Rivers JK. Is there more than one road to melanoma? Lancet. 2004;363:728–730.

    PubMed  Google Scholar 

  107. Maldonado JL, Fridlyand J, Patel H, et al. Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst. 2003;95:1878–1890.

    CAS  PubMed  Google Scholar 

  108. Garrett AB. Skin cancer in people of color. In: Snow N, Mikhail GR (eds) Mohs Micrographic Surgery. Madison: University of Wisconsion Press, 2004.

    Google Scholar 

  109. Callen JP, Bickers DR, Moy RL. Actinic keratoses. J Am Acad Dermatol. 1997;36:650–653.

    CAS  PubMed  Google Scholar 

  110. Kurban RS, Kurban AK. Common skin disorders of aging: diagnosis and treatment. Geriatrics. 1993;48:30–1, 35–6, 39–42.

    CAS  PubMed  Google Scholar 

  111. Berwick M. Counterpoint: sunscreen use is a safe and effective approach to skin cancer prevention. Cancer Epidemiol. Biomarkers Prev. 2007;16:1923–1924.

    CAS  Google Scholar 

  112. Xie J. Molecular biology of basal and squamous cell carcinomas. In: Reichrath J (ed) Sunlight, Vitamin D and Skin Cancer. Austin: Landes Bioscience, 2008.

    Google Scholar 

  113. Wartman D, Weinstock M. Are we overemphasizing sun avoidance in protection from melanoma? Cancer Epidemiol Biomarkers Prev. 2008;17:469–470.

    CAS  Google Scholar 

  114. Piacquadio DJ, Chen DM, Farber HF, et al. Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. Arch Dermatol. 2004;140:41–46.

    CAS  PubMed  Google Scholar 

  115. Sandberg C, Stenquist B, Rosdahl I, et al. Important factors for pain during photodynamic therapy for actinic keratosis. Acta Derm Venereol. 2006;86:404–408.

    Google Scholar 

  116. Pariser DM, Lowe NJ, Stewart DM, et al. Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol. 2003;48:227–232.

    PubMed  Google Scholar 

  117. Wennberg AM, Lindholm LE, Alpsten M, et al. Treatment of superficial basal cell carcinomas using topically applied delta-aminolaevulinic acid and a filtered xenon lamp. Arch Dermatol Res. 1996;288:561–564.

    CAS  PubMed  Google Scholar 

  118. Horn M, Wolf P, Wulf HC, et al. Topical methyl aminolaevulinate photodynamic therapy in patients with basal cell carcinoma prone to complications and poor cosmetic outcome with conventional treatment. Br J Dermatol. 2003;149:1242–1249.

    CAS  PubMed  Google Scholar 

  119. Loven K, Stein L, Furst K, et al. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther. 2002;24:990–1000.

    CAS  PubMed  Google Scholar 

  120. Weiss J, Menter A, Hevia O, et al. Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks. Cutis. 2002;70:22–29.

    PubMed  Google Scholar 

  121. Wolf JEJ, Taylor JR, Tschen E, et al. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol. 2001;40:709–713.

    CAS  PubMed  Google Scholar 

  122. Rivers JK, Arlette J, Shear N, et al. Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel. Br J Dermatol. 2002;146:94–100.

    CAS  PubMed  Google Scholar 

  123. Fariba I, Ali A, Hossein SA, et al. Efficacy of 3% diclofenac gel for the treatment of actinic keratoses: a randomized, double-blind, placebo controlled study. Indian J Dermatol Venereol Leprol. 2006;72:346–349.

    PubMed  Google Scholar 

  124. Grimaître M, Etienne A, Fathi M, et al. Topical colchicine therapy for actinic keratoses. Dermatology (Basel). 2000;200:346–348.

    Google Scholar 

  125. Akar A, Bülent Taştan H, Erbil H, et al. Efficacy and safety assessment of 0.5% and 1% colchicine cream in the treatment of actinic keratoses. J Dermatolog Treat. 2001;12:199–203.

    CAS  PubMed  Google Scholar 

  126. Stockfleth E, Meyer T, Benninghoff B, et al. A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol. 2002;138:1498–1502.

    CAS  PubMed  Google Scholar 

  127. Salasche SJ, Levine N, Morrison L. Cycle therapy of actinic keratoses of the face and scalp with 5% topical imiquimod cream: an open-label trial. J Am Acad Dermatol. 2002;47:571–577.

    PubMed  Google Scholar 

  128. Persaud AN, Shamuelova E, Sherer D, et al. Clinical effect of imiquimod 5% cream in the treatment of actinic keratosis. J Am Acad Dermatol. 2002;47:553–556.

    PubMed  Google Scholar 

  129. Lebwohl M, Dinehart S, Whiting D, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol. 2004;50:714–721.

    PubMed  Google Scholar 

  130. Beutner KR, Geisse JK, Helman D, et al. Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J Am Acad Dermatol. 1999;41:1002–1007.

    CAS  PubMed  Google Scholar 

  131. Marks R, Gebauer K, Shumack S, et al. Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. J Am Acad Dermatol. 2001;44:807–813.

    CAS  PubMed  Google Scholar 

  132. Geisse JK, Rich P, Pandya A, et al. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study. J Am Acad Dermatol. 2002;47:390–398.

    PubMed  Google Scholar 

  133. Sterry W, Ruzicka T, Herrera E, et al. Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion. Br J Dermatol. 2002;147:1227–1236.

    CAS  PubMed  Google Scholar 

  134. Shumack S, Robinson J, Kossard S, et al. Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens. Arch Dermatol. 2002;138:1165–1171.

    CAS  PubMed  Google Scholar 

  135. Spencer J. Actinic Keratoses. http://www.emedicine.com/derm/topic9.htm. cit.

  136. Ulrich C, Busch JO, Meyer T, et al. Successful treatment of multiple actinic keratoses in organ transplant patients with topical 5% imiquimod: a report of six cases. Br J Dermatol. 2006;155:451–454.

    CAS  PubMed  Google Scholar 

  137. Ortonne J. From actinic keratosis to squamous cell carcinoma. Br J Dermatol. 2002;146(61):20–23.

    PubMed  Google Scholar 

  138. Weinstock MA. Epidemiologic investigation of nonmelanoma skin cancer mortality: the Rhode Island Follow-Back Study. J Invest Dermatol. 1994;102:6S–9S.

    CAS  PubMed  Google Scholar 

  139. Weinstock MA. Epidemiology of nonmelanoma skin cancer: clinical issues, definitions, and classification. J Invest Dermatol. 1994;102:4S–5S.

    CAS  PubMed  Google Scholar 

  140. Soehnge H, Ouhtit A, Ananthaswamy ON. Mechanisms of induction of skin cancer by UV radiation. Front Biosci. 1997;2:d538–51.

    CAS  PubMed  Google Scholar 

  141. Leman JA, McHenry PM. Basal cell carcinoma: still an enigma. Arch Dermatol. 2001;137:1239–1240.

    CAS  PubMed  Google Scholar 

  142. Moloney FJ, Comber H, O’Lorcain P, et al. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol. 2006;154:498–504.

    CAS  PubMed  Google Scholar 

  143. Zhang H, Ping XL, Lee PK, et al. Role of PTCH and p53 genes in early-onset basal cell carcinoma. Am J Pathol. 2001;158:381–385.

    CAS  PubMed  Google Scholar 

  144. Scotto J, Fears TR, Fraumeni JF. Incidence of non-melanoma skin cancer in the United States. Bethesda: US Department of Health and Human Services, National Institutes of Health, 1983.

    Google Scholar 

  145. Rigel DS, Carucci JA. Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin. 2000;50:215–36, quiz 237–40.

    CAS  PubMed  Google Scholar 

  146. Hoersch B, Leiter U, Garbe C. Is head and neck melanoma a distinct entity? A clinical registry-based comparative study in 5702 patients with melanoma. Br J Dermatol. 2006;155:771–777.

    CAS  PubMed  Google Scholar 

  147. Detailed Guide to Skin Cancer. Basal and Squamous cell. June, 2008. American Cancer Society electronic publication. http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?dt=51.

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Authors and Affiliations

  1. The Procter & Gamble Company, Winton Hill Business Center, Cincinnati, OH, USA

    Miranda A. Farage, Kenneth W. Miller & Isaac M. Neuhaus

  2. San Gallicano Dermatological Institute, Rome, Italy

    Enzo Berardesca

  3. Department of Dermatology, University of California, San Francisco, CA, USA

    Howard I. Maibach

Authors
  1. Miranda A. Farage
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  2. Kenneth W. Miller
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  3. Enzo Berardesca
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  4. Howard I. Maibach
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  5. Isaac M. Neuhaus
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Editor information

Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

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Farage, M.A., Miller, K.W., Berardesca, E., Maibach, H.I., Neuhaus, I.M. (2010). Neoplastic Skin Lesions in the Elderly Patient. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_55

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  • DOI: https://doi.org/10.1007/978-3-540-89656-2_55

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

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