Actin Cytoskeleton, Multi-scale Modeling
Actin polymerization; Cell motility; Force generation
Cell locomotion is essential in numerous processes such as embryonic development, the immune response, and wound healing. Movement requires forces, which are generated by utilizing the chemical free energy in ATP to build actin networks and power myosin motor contraction. In solution, actin monomers (G-actin) assemble into two-stranded filaments (F-actin), bundles of filaments and gels. The helical F-actin filament is asymmetric, with a barbed or plus end and a pointed or minus end, and this leads to asymmetric reaction kinetics at the two ends. In solution, G-actin primarily contains ATP, but a G-ATP monomer that is incorporated in a filament subsequently hydrolyzes its bound ATP into ADP-Pi-actin and releases the phosphate Pi to yield G-ADP. As a result maintenance of actin structures at steady state requires a constant energy supply in the form of ATP. All three G-actin types bind to filament tips, but with...
Research supported by NSF grants DMS-0517884 and DMS-0817529.
- 6.Bray, D.: Cell Movements: From Molecules to Motility. Garland Pub., New York (2001)Google Scholar
- 8.Howard, J.: Mechanics of Motor Proteins and the Cytoskeleton. Sinauer Associates, Inc, Sunderland (2001)Google Scholar
- 9.Boal, D.: Mechanics of the Cell. Cambridge University Press, Cambridge (2002)Google Scholar
- 14.Hu, J., Othmer, H.G.: A theoretical analysis of filament length fluctuations in actin and other polymers. J. Math. Biol., DOI 10.1007/S00285-010-0400-6 (2011)Google Scholar