Encyclopedia of Applied and Computational Mathematics

2015 Edition
| Editors: Björn Engquist

Angiogenesis, Computational Modeling Perspective

  • Amina A. Qutub
  • Aleksander S. Popel
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-70529-1_162

Introduction

Angiogenesis, the growth of capillaries from existing microvasculature, arises in dozens of physiological and pathological conditions. It is critical to wound healing and response to exercise. Angiogenesis also plays a pivotal role in the progression of cancer and tissue recovery after stroke. As such, angiogenesis has been the target of numerous therapies. However, so far, clinical trials and approved drugs targeting angiogenesis have performed below their potential [1, 2]. In part this is because drugs have been limited in their targets. Emerging angiogenic treatments are more likely to be multimodal, targeting multiple molecules or cells [3]. In addition, the need for tighter control over the degree, duration, and efficacy of new capillary growth by proper timing and dosing of therapies has been recognized. To harness the full therapeutic use of angiogenesis, a greater quantitative understanding of the process is needed. Modeling becomes a vital tool to capture the...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Amina A. Qutub
    • 1
  • Aleksander S. Popel
    • 2
  1. 1.Department of BioengineeringRice UniversityHoustonUSA
  2. 2.Systems Biology Laboratory, Department of Biomedical Engineering, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA