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Claude Syndrome

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Definition

Claude syndrome refers to the set of signs and symptoms associated with unilateral tegmental lesions of the dorsomedial midbrain. Named after Henri Charles Jules Claude, who described the condition in 1912, this particular intramedullary brainstem syndrome most commonly involves unilateral infarction of the medial half of the red nucleus and superior cerebellar peduncles after decussation.

Etiology

Infarction of the dorsomedial midbrain may arise secondary to occlusion of a branch of the posterior cerebral artery. These events are most commonly caused by preexisting cerebrovascular disease or malignancy. Large artery disease producing emboli or in situ thrombosis account for the majority of mesencephalic infarct mechanisms, while cardioembolism and small-vessel disease are associated with 25% of cases.

Disruption of blood flow in the posterior cerebral artery may compromise the following neuronal tracts within the midbrain tegmentum, thus yielding the characteristic signs...

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Correspondence to Andrew G. Lee .

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DeBacker, D.L., Davis, A.R., Almarzouqi, S.J., Lee, A.G. (2018). Claude Syndrome. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69000-9_1304

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  • DOI: https://doi.org/10.1007/978-3-540-69000-9_1304

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-68292-9

  • Online ISBN: 978-3-540-69000-9

  • eBook Packages: MedicineReference Module Medicine