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Binding Potential

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Encyclopedia of Psychopharmacology
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Synonyms

BP; BP1 ; BP2 ; BPF ; BPND ; BPP ; V3

Definition

A composite parameter used in PET and SPECT imaging that is proportional to the product of receptor density and affinity of the radioligand for the receptor, or Bmax/KD. The binding potential is also equal to the limiting value of the ratio of receptor-bound to free radioligand as the free concentration approaches zero. The nature of the constant of proportionality depends on the free pool being referred to. When the binding potential is measured relative to a reference tissue, the constant of proportionality is fND, the free fraction of the free plus nonspecifically-bound ligand in brain, and the binding potential is termed BPND. When measured relative to the radioligand concentration in arterial plasma, the constant is fP, the fraction of radioligand in arterial plasma that is not protein bound, and the binding potential is termed BPP. Finally, if fPis measured and accounted for so that the true free concentration in...

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© 2010 Springer-Verlag Berlin Heidelberg

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Slifstein, M. (2010). Binding Potential. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_792

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