Definition
Tacyphylaxis is the rapid development of tolerance to the effect of a drug. That is, the response to a drug rapidly decreases after a few initial doses. In the case of hallucinogens, the process is thought to be a result of rapid desensitization and internalization of serotonin 5-HT2A receptor.
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Nichols, D.E. (2010). Tachyphylaxis. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_641
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DOI: https://doi.org/10.1007/978-3-540-68706-1_641
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-68698-9
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