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The term microiontophoresis is derived from the ancient Greek term phoretikos, which refers to the production or induction of movement. Microiontophoresis is a technique with which drugs and other ionized particles can be ejected in very small amounts from solutions contained in glass micropipettes. This ejection is accomplished by applying a voltage across the micropipette and causing the electrode to become polarized. Ionized particles in solution migrate in the applied field and will be ejected from the tip as they carry the current into the tissue. This technique is widely used to determine the effects of various substances on firing parameters of both central and peripheral neurons and muscles. In investigating the phenomenon of synaptic transmission at the neuromuscular junction, during the 1950s, this technique became very popular. A technique appropriate for the study of synaptic pharmacology was first realized by Nastuk (1953) and was later...
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Invernizzi, R., Esposito, E. (2010). Microiontophoresis and Related Methods. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_300
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DOI: https://doi.org/10.1007/978-3-540-68706-1_300
Publisher Name: Springer, Berlin, Heidelberg
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