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Extracellular Recording

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Encyclopedia of Psychopharmacology

Synonyms

Measurement of neuronal activity

Definition

Extracellular recordings are used to monitor neuronal activity from outside the cell. It provides a means to measure patterns of action potentials within many areas of the peripheral and central nervous systems. In addition, massed activity can also be recorded. The effects of pathology and drugs can be investigated over extended time-courses using this technique.

Principles and Role in Psychopharmacology

Principles of Extracellular Recording

Richard Caton (1842–1926), who performed electroencephalography (EEG) from the surface of living brains in animals, first discovered the electrical nature of the brain (Caton 1875). These electrical impulses, in the form of action potentials, underlie the information processing capabilities of the central nervous system (CNS). The pattern, frequency, and coding of this activity allows messages to be transferred from one area to another of the CNS. Extracellular recordings represent a very...

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References

  • Alvarez de Toledo G, Fernández-Chacón R, Fernández JM (1993) Release of secretory products during transient vesicle fusion. Nature 363(6429):554–558

    Article  PubMed  CAS  Google Scholar 

  • Bliss T, Lømo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232(2):331–356

    PubMed  CAS  Google Scholar 

  • Caton R (1875) The electric currents of the brain. Br Med J 2:278

    Google Scholar 

  • Chow RH, von Rüden L, Neher E (1992) Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells. Nature 356(6364):60–63

    Article  PubMed  CAS  Google Scholar 

  • Neher E (1993) Cell Physiology. Secretion without full fusion. Nature 363(6429):497–498

    Article  PubMed  CAS  Google Scholar 

  • O'Keefe J, Dostrovsky J (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171–175

    Article  PubMed  Google Scholar 

  • Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002 Dec) Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5(12):1319–1326

    Article  PubMed  CAS  Google Scholar 

  • Urch CE, Dickenson AH (2003) In vivo single unit extracellular recordings from spinal cord neurones of rats. Brain Res Brain Res Protoc 12(1):26–34

    Article  PubMed  CAS  Google Scholar 

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Harvey, V.L., Dickenson, A.H. (2010). Extracellular Recording. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_290

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