Definition
PDE3 inhibitors are drugs that inhibit phosphodiesterase3, which hydrolyzes cAMP. PDE3 is found in the heart and smooth muscles, but also throughout the brain. There are two PDE3 inhibitors on the market; milrinone (Primacor) for the treatment of congestive heart failure and cilostazol (Pletal) for the treatment of intermittent claudication. Cilostazol is also in clinical development for the treatment of stroke.
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Prickaerts, J. (2010). PDE3 Inhibitors. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_1540
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DOI: https://doi.org/10.1007/978-3-540-68706-1_1540
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-68698-9
Online ISBN: 978-3-540-68706-1
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