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The plasma half-life of a drug (t½) is the time necessary to reduce the plasma concentration by half, for example, to decrease from 100 to 50 mg/L. The knowledge of the half-life is useful for the determination of the frequency of administration of a drug (the number of intakes per day) for obtaining the desired plasma concentration. Generally, the half-life of a particular drug is independent of the dose administered. In certain exceptional cases, it varies with the dose: it can increase or decrease according to, for example, the saturation of a mechanism (elimination, binding to plasma proteins, etc.).
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© 2010 Springer-Verlag Berlin Heidelberg
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Wolff, K. (2010). Elimination Half-Life. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_1531
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DOI: https://doi.org/10.1007/978-3-540-68706-1_1531
Publisher Name: Springer, Berlin, Heidelberg
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