Definition
CAMTA1 is a candidate tumor suppressor gene encoding a member of a protein family designated as calmodulin-binding transcription activators (CAMTAs). It resides within a distal portion of chromosomal arm 1p that is frequently deleted in a wide range of human malignancies.
Characteristics
CAMTA1 maps to 1p36.31-p36.23 and its 23 exons are spread over 982.5 kb. The 6,582 bp cDNA encodes a protein of 1,673 amino acids. The protein’s primary structure contains a nuclear localization signal, two DNA-binding domains (CG-1 and TIG), a transcription activation domain, calmodulin binding motifs (IQ motifs), and ankyrin domains. Although the expression of CAMTA1 is seen in various organs, highest levels are found in neuronal tissues. Information on the physiologic roles of CAMTAs is scarce and most data derive from plant and drosophila studies.
CAMTAs are transcription factors that typically bind to CGCG boxes via their CG-1 domain. An alternative mechanism of transcriptional...
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References
Barbashina V, Salazar P, Holland EC et al. (2005) Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Clin Cancer Res 11(3):1119–1128
Bouche N, Scharlat A, Snedden W et al. (2002) A novel family of calmodulin-binding transcription activators in multicellular organisms. J Biol Chem 277(24):21851–21861
Henrich KO, Claas A, Praml C et al. (2007) Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. Eur J Cancer 43(3):607–616
Henrich KO, Fischer M, Mertens D et al. (2006) Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Clin Cancer Res 12(1):131–138
Kim MY, Yim SH, Kwon MS et al. (2006) Recurrent genomic alterations with impact on survival in colorectal cancer identified by genome-wide array comparative genomic hybridization. Gastroenterology 131(6):1913–1924
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© 2008 Springer-Verlag Berlin Heidelberg New York
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Henrich, KO., Westermann, F. (2008). CAMTA1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_793
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DOI: https://doi.org/10.1007/978-3-540-47648-1_793
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36847-2
Online ISBN: 978-3-540-47648-1
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