Encyclopedia of Cancer

2009 Edition
| Editors: Manfred Schwab

Photochemoprevention

  • Anne M. VanBuskirk
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-47648-1_4549

Definition

“Photochemoprevention” has 2 very different meanings. The term was first coined in 2001 to describe  chemoprevention of skin damage, including skin  carcinogenesis ( Photocarcinogenesis), due to  ultraviolet (UV) light ( Solar Ultraviolet light,  UV radiation). A second use of the word “photo-chemoprevention,” as defined in 2003, is to refer to the combination therapy of  pulsed dye laser (PDL) to inhibit  angiogenesis and chemoprevention to block both proliferation of cancer cells and tumor revascularization ( vascular targeting agents in cancer). The comments below will describe the term “photochemoprevention” as originally used.

Characteristics

Photochemoprevention can refer to the use of any chemopreventive agent, either ingested or topically applied, to block the damaging effects of UV light. UV light, in particular UVB light, is directly responsible for much of the damage leading to skin cancer development, especially basal cell ( Basal Cell Carcinoma) and  squamous...

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References

  1. 1.
    Afaq F, Adhami VM, Mukhtar H (2005) Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutat Res 571:153–173PubMedGoogle Scholar
  2. 2.
    Bowden GT (2004) Prevention of non-melanoma skin cancer by targeting ultraviolet-b-light signaling. Nat Rev Cancer 4:23–35PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 2008

Authors and Affiliations

  • Anne M. VanBuskirk
    • 1
  1. 1.Medical Affairs DepartmentTAP Pharmaceutical Products, Inc.Lake ForestUSA