Synonyms
Galanin receptor type 1; Galanin receptor type 2; Galanin receptor type 3; Galanin receptor-1; Galanin receptor-2; Galanin receptor-3; Galanin-R1; Galanin-R2; Galanin-R3; Gal-R1; Gal-R2; Gal-R3; GalR1; GalR2; GalR3; GAL1; GAL2; GAL3
Definition
The galanin receptors form a distinct subfamily of G protein-coupled receptors (GPCRs). Three receptor subtypes have been cloned and characterized: GAL1, GAL2, GAL3. Structurally, each receptor is a typical GPCR, i.e., a monomeric serpentine protein with seven helical transmembrane domains, an extracellularly directed N-terminus and an intracellularly directed C-terminus. Other GPCRs which are similar at the amino acid level (30–38%) include the somatostatin sst4 and sst5 receptor subtypes, the ORL1 (nociceptin) receptor and the GPR54 (KiSS-1) receptor. These galanin receptors are thought to mediate various effects of galanin and galanin-related peptide, such as those mood regulation, cognition, pain, growth, and energy balance [1, 2, 3]....
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References
Walton KM, Chin JE, Duplantier AJ et al (2006) Galanin function in the central nervous system. Curr Opin Drug Discov Dev 9:560–570
Ogren SO, Koteeva E, Hokfelt T et al (2006) Galanin receptor antagonists: a potential novel pharmacological treatment for mood disorders. CNS Drugs 20:633–654
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Swanson CJ, Blackburn TP, Zhang X et al (2005) Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci USA 102:17489–17494
Barr AM, Kinney JW, Hill MN et al (2006) A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci Lett 405:111–115
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© 2008 Springer-Verlag Berlin Heidelberg New York
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Walker, M.W., Packiarajan, M., Smith, K.E. (2008). Galanin Receptors. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38918-7_62
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DOI: https://doi.org/10.1007/978-3-540-38918-7_62
Publisher Name: Springer, Berlin, Heidelberg
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