Synonym
Blood flow
Definitions
Perfusion is the nutritive flow of blood through tissues. There is a growing interest in imaging perfusion in tumours. Perfusion can be a measure of pharmacodynamic response to anti‐angiogenic drugs and vascular disrupting agents and many chemotherapeutic agents. Perfusion is also a prognostic factor, with perfusion being both a poor and good prognostic factor.
Volumetric imaging with CT or MRI is less useful for assessing efficacy of anti‐angiogenic drugs as these are cytostatic rather than causing tumour shrinkage. Hence, the increased need for direct imaging of effects on tumour vasculature.
Perfusion is governed by tumour vasculature and perfusion pressure. Tumour blood vessels have structural and functional abnormalities. This includes irregular branching, increased permeability and independence from normal flow control mechanisms. Such abnormalities lead to variable and inadequate perfusion. Angiogenesis is the formation of new vessels, essential...
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© 2008 Springer-Verlag Berlin Heidelberg New York
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Price, P., Charnley, N., Matthews, J. (2008). Perfusion, Neoplasms. In: Baert, A.L. (eds) Encyclopedia of Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35280-8_1911
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DOI: https://doi.org/10.1007/978-3-540-35280-8_1911
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-35278-5
Online ISBN: 978-3-540-35280-8
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