Notch receptors are single-pass transmembrane receptor proteins involved in cell-cell communication processes. There are composed of functional extracellular, transmembrane, and intracellular domains. Members of the Delta-like (DLL1, DLL3, DLL4) and the Jagged (JAG1, JAG2) families, which are located in the signal-sending cell, may serve as ligands for Notch signaling receptors. The notch signaling pathway plays an important role in cellular proliferation, differentiation, and apoptosis.
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© 2012 Springer-Verlag Berlin Heidelberg
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(2012). Notch. In: Mooren, F.C. (eds) Encyclopedia of Exercise Medicine in Health and Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29807-6_3207
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DOI: https://doi.org/10.1007/978-3-540-29807-6_3207
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