Encyclopedia of Exercise Medicine in Health and Disease

2012 Edition
| Editors: Frank C. Mooren


  • Timothy M. GriffinEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29807-6_311



Osteoarthritis is a common  synovial jointdisease characterized by the failed and often aberrant repair of damaged joint tissue. Osteoarthritis pathology typically involves progressive focal areas of damage to the articular cartilage on load-bearing surfaces. Additional pathologies that are involved in osteoarthritis to varying degrees include abnormal bone remodeling along the joint margins and in the subchondral region, meniscal tears, mild synovitis, and changes in ligament, periarticular muscle, and peripheral nerve function. When the disease is advanced, osteoarthritic changes can be detected on plain radiographs as a narrowing of joint space (due to cartilage loss), the development of osteophytes (boney outgrowths along the joint margin), and changes in subchondral bone density. Clinically, osteoarthritis is associated with restricted joint range of movement, stiffness, pain, cracking of joints (crepitus), and...

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  1. 1.
    Lane NE, Brandt K, Hawker G, Peeva E, Schreyer E, Tsuji W, Hochberg MC (2011) OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthr Cartil 19(5):478–482CrossRefPubMedGoogle Scholar
  2. 2.
    Murphy L, Schwartz TA, Helmick CG, Renner JB, Tudor G, Koch G, Dragomir A, Kalsbeek WD, Luta G, Jordan JM (2008) Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum 59(9):1207–1213PubMedCentralCrossRefPubMedGoogle Scholar
  3. 3.
    Griffin TM, Guilak F (2005) The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev 33(4):195–200CrossRefPubMedGoogle Scholar
  4. 4.
    Hootman JM, Murphy L, Helmick CG (2011) Arthritis as a potential barrier to physical activity among adults with obesity – United States, 2007 and 2009. Morb Mortal Wkly Rep 60(19):614–618Google Scholar
  5. 5.
    Roddy E, Zhang W, Doherty M, Arden NK, Barlow J, Birrell F, Carr A, Chakravarty K, Dickson J, Hay E, Hosie G, Hurley M, Jordan KM, McCarthy C, McMurdo M, Mockett S, O’Reilly S, Peat G, Pendleton A, Richards S (2005) Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee–the MOVE consensus. Rheumatology (Oxford) 44(1):67–73CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Free Radical Biology and Aging Research Program, Department of Biochemistry and Molecular Biology, Department of Geriatric MedicineOklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Reynolds Oklahoma Center on AgingOklahoma CityUSA