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Diabetes Mellitus, Myopathy

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Synonyms

Diabetic myopathy; Insulin-dependent diabetic myopathy; Juvenile-onset diabetic myopathy

Definition

Diabetic myopathy refers to the broad spectrum of pathophysiological alterations to skeletal muscle in response to the diabetic biochemical, hormonal, and cellular environment. This chapter will describe those alterations specific to type 1 diabetes mellitus (T1DM). T1DM causes a host of changes in muscle that can be detected with molecular or biochemical techniques, with microscopy of histochemically prepared tissue samples, or with functional testing (e.g., exercise testing). Typically T1DM is associated with a loss of muscle mass and strength, the former presumably causing the latter [1].

Characteristics

Skeletal Muscle Function in T1DM

Many studies have examined exercise capacity in T1DM, the most common findings being small, but significant losses in maximal aerobic capacity or peak work capacity. The studies that detected significant decreases in aerobic fitness usually...

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Diabetes Mellitus, Myopathy. Fig. 1
Diabetes Mellitus, Myopathy. Fig. 2

References

  1. Krause MP, Riddell MC, Hawke TJ (2011) Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms. Pediatr Diabetes 12(4 Pt 1):345–364

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  2. Jakobsen J, Reske-Nielsen E (1986) Diffuse muscle fiber atrophy in newly diagnosed diabetes. Clin Neuropathol 5:73–77

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  3. Iscoe KE, Campbell JE, Jamnik V, Perkins BA, Riddell MC (2006) Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring system. Diabetes Technol Ther 8:627–635

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Correspondence to Matthew P. Krause .

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© 2012 Springer-Verlag Berlin Heidelberg

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Krause, M.P., Hawke, T.J. (2012). Diabetes Mellitus, Myopathy. In: Mooren, F.C. (eds) Encyclopedia of Exercise Medicine in Health and Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29807-6_263

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  • DOI: https://doi.org/10.1007/978-3-540-29807-6_263

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-36065-0

  • Online ISBN: 978-3-540-29807-6

  • eBook Packages: MedicineReference Module Medicine