Encyclopedia of Exercise Medicine in Health and Disease

2012 Edition
| Editors: Frank C. Mooren

Mitochondrial Biogenesis

  • David A. HoodEmail author
  • Kaustabh Singh
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29807-6_135



Mitochondrial biogenesis refers to an increase in mitochondrial volume as well as possible changes in mitochondrial composition. In skeletal muscle, this is an adaptation that results from repeated bouts of exercise (Fig.  1a). Mitochondrial biogenesis in skeletal muscle promotes a shift toward a greater  oxidative capacity in the muscle fibers, leading to higher  muscle endurance.
This is a preview of subscription content, log in to check access.


  1. 1.
    Hood DA (2001) Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 90(3):1137–1157PubMedGoogle Scholar
  2. 2.
    Hood DA, Irrcher I, Ljubicic V, Joseph AM (2006) Coordination of metabolic plasticity in skeletal muscle. J Exp Physiol 209(12):2265–2275Google Scholar
  3. 3.
    Irrcher I, Ljubicic V, Kirwan AF, Hood DA (2008) AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells. PLoS One 3:e3614PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, Holloszy JO (2007) Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression. J Biol Chem 282(1):194–199PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Muscle Health Research CentreSchool of Kinesiology & Health Science, York UniversityTorontoCanada