Encyclopedia of Exercise Medicine in Health and Disease

2012 Edition
| Editors: Frank C. Mooren

Metabolism, Lipid

  • Asker JeukendrupEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29807-6_133



Lipid metabolism is the sum of all processes involved in the synthesis and degradation of lipids.

Basic Mechanisms

The most common form of lipids is the triglyceride or triacylglycerol. Most FAs are stored in the form of triacylglycerols in subcutaneous adipose tissue. Before these FAs are oxidized, they must be mobilized and transported to the site of oxidation. The adipocyte contains lipases that break down triacylglycerols. Hormone-sensitive lipase (HSL) splits triacylglycerols into FAs and glycerol and, as its name implies, is regulated by hormones. Adipocytes also contain triacylglycerol lipase and enzyme that splits off the first fatty acids resulting in the formation of a diacylglycerol (DAG). HSL may be translocated to the triacylglycerol in the cell and subsequently activated. Conversion of the inactive form of HSL into the active form mainly depends on the sympathetic nervous system and circulating...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.School of Sport and Exercise SciencesThe University of BirminghamEdgbastonUK