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Tramadol Hydrochloride

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Synonyms

Tramadol; Tramal; Zydol

Definition

An analogue of codeine, tramadol hydrochloride is a centrally acting analgesic. It is not derived from natural sources, and structurally is not related to opioids; but does exhibit certain opioid characteristics.

Characteristics

Mechanism

Animal and in-vitro studies suggest that in addition to its mu-opioid effect, tramadol synergistically inhibits the reuptake of norepinephrine (NE) and serotonin, and simultaneously stimulates the pre-synaptic release of serotonin (Raffa and Fridericks 1996; Bamigbade et al. 1997). It has a weak affinity for opioid receptors and is less potent than morphine. The analgesic effect is apportioned between the opioid and monoaminergic components (Desmoules et al. 1996). The response is dose-dependent but the relationship between analgesic effect and serum concentration varies considerably between individuals.

Pharmacokinetics

After oral administration, tramadol is rapidly and almost completely absorbed with a...

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References

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© 2007 Springer-Verlag Berlin Heidelberg

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Govind, J. (2007). Tramadol Hydrochloride. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_4551

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  • DOI: https://doi.org/10.1007/978-3-540-29805-2_4551

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43957-8

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