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Toxic Neuropathies

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Definition

Toxic neuropathies are peripheral nerve disorders due to acute or chronic adverse effects of chemicals or medications which occur in individuals or as an outbreak in a certain population after occupational exposure or environmental contamination.

Characteristics

Neurons, Axons and Neuropathy

Neuropathies are diseases of the peripheral nervous system from various etiologies, including metabolic disorders, such as diabetic neuropathy due to diabetes mellitus (Vinik AI et al. 2000), and toxic effects of chemotherapy for cancer. In the peripheral nervous system, the length of axons is much greater than the diameter of the neuronal cell body. This results in a much larger cytoplasmic volume in the entire axon compared to the volume of the neuronal cell body, often by several orders of magnitude. As an example, take a motor neuron of an adult human. The diameter of a motor neuron in the lumbar spinal cord is up to 100 µm; in contrast, the length of a motor axon from this motor...

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References

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© 2007 Springer-Verlag Berlin Heidelberg

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Hsieh, ST. (2007). Toxic Neuropathies. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_4540

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  • DOI: https://doi.org/10.1007/978-3-540-29805-2_4540

  • Publisher Name: Springer, Berlin, Heidelberg

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