Definition
Tachykinins are a family of structurally-related peptides, widely scattered in vertebrate and invertebrate tissues. Mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). All mammalian tachykinins share a common C-terminal amino acid sequence, i.e. Phe-x-Gly-Leu- MetNH, which is the minimal structural motif for the activation of tachykinin receptors (NK1, NK2 and NK3). Pharmacologically, they all cause hypotension in mammals, contraction of gut and bladder smooth muscle, and secretion of saliva.
Neuropeptide Release in the Skin
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© 2007 Springer-Verlag Berlin Heidelberg
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(2007). Tachykinin. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_4366
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DOI: https://doi.org/10.1007/978-3-540-29805-2_4366
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43957-8
Online ISBN: 978-3-540-29805-2
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