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Encyclopedia of Pain pp 1320–1322Cite as

Neuropeptide Release in Inflammation

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Synonyms

Inflammation, Neuropeptide Release

Definition

Neuropeptides are a group of small peptides with 4 to more than 40 amino acids found in the central and peripheral nervous system. This essay focuses on neuropeptides that are released into peripheral tissues upon neuronal activation; that is the case, for example, during an inflammation. The neuropeptides are synthesized in the cell body of primary afferent (sensory) neurons located in the dorsal root ganglia and are transported through the axons into preferentially the peripheral nerve endings. The best-known neuropeptides in primary afferent neurons are substance P and calcitonin gene-related peptide.

Characteristics

Nociceptors are primary afferent neurons many of which are characterized by their ability to release neuropeptides such as substance P (SP, 11 amino acids), calcitonin gene-related peptide (CGRP, 37 amino acids) and neurokinins(10 amino acids) from their peripheral terminals upon noxious stimulation (Maggi et al....

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  • DOI: 10.1007/978-3-540-29805-2_2690
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References

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Author information

Authors and Affiliations

  1. Sanofi–Aventis Deutschland GmbH, Frankfurt, Germany

    Beate Averbeck

Authors
  1. Beate Averbeck
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Editor information

Editors and Affiliations

  1. Physiological Institute, University of Würzburg, Würzburg, Germany

    Robert F. Schmidt

  2. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA

    William D. Willis

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© 2007 Springer-Verlag Berlin Heidelberg

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Averbeck, B. (2007). Neuropeptide Release in Inflammation. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_2690

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  • DOI: https://doi.org/10.1007/978-3-540-29805-2_2690

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43957-8

  • Online ISBN: 978-3-540-29805-2

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