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Vesicular Neurotransmitter Transporter

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Encyclopedia of Neuroscience

Definition

Many neurotransmitters are secreted from neural and non-neural cells through exocytosis of vesicles. Vesicular neurotransmitter transporters are membrane transporters responsible for the accumulation of neurotransmitters in such secretory vesicles [13]. Typical neurotransmitters secreted through exocytosis are acetylcholine, dopamine, histamine, GABA and glutamate. The vesicular neurotransmitter transporters are located in the vesicle membrane, and transport neurotransmitters across the membrane using an electrochemical gradient of protons generated by V-type H+-ATPase (Fig. 1).

Vesicular Neurotransmitter Transporter. Figure 1
figure 227

Neurotransmitters are sequestered to vesicles by the vesicular neurotransmitter transporters using an electrochemical gradient of protons established by V-ATPase. Concentrated neurotransmitters are secreted through exocytosis.

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Omote, H., Moriyama, Y. (2009). Vesicular Neurotransmitter Transporter. In: Binder, M.D., Hirokawa, N., Windhorst, U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29678-2_6283

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