Definition and Characteristics
The literal meaning of restenosis is the reoccurrence of stenosis. Coronary restenosis occurs in coronary arteries that had been treated with various percutaneous coronary interventions (PCIs), aiming at a free arterial blood flow (TIMI III-flow).
Prevalence
In 1997, over one million PCIs have been performed worldwide, in 2001, the number rose to over two million. During the first three decades, after the first PCI in an awake human in 1977 (Dr. Andreas Gruentzig, Zürich, Switzerland), restenosis occurred in 20–40% of the patients within 3–6 months after the intervention, almost independently of the technique applied. The combination of balloon/stents, balloon/irradiation, and balloon/drug eluting stents (DES) has modified the characteristics of restenosis. After balloon/DES, the percentage of patients suffering from restenosis was reduced below 10% [1].
Molecular and Systemic Pathophysiology
The pathophysiology of restenosis is very complex, an...
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References
Mitra AK, Agrawal DK (2006) In stent restenosis: bane of the stent era. J Clin Pathol 59:232–239
Welt FG, Rogers C (2002) Inflammation and restenosis in the stent era. Arterioscler Thromb Vasc Biol 22:1769–1776
Costa MA, Simon DI (2005) Molecular basis of restenosis and drug eluting stents. Circulation 111:2257–2273
Boehm M, Nabel EG (2001) Cell cycle and cell migration: new pieces to the puzzle. Circulation 103:2879–2881
Berman DS, Hachamovitch R, Shaw LJ, Friedman JD, Hayes SW, Thompson LE, Fieno DS, Germano G, Slomka P, Wong ND, Kang X, Rozanski A (2006) Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: assessment of patients with suspected coronary artery disease. J Nucl Med 47:74–82
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Voisard, R. (2009). Coronary Restenosis. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_414
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DOI: https://doi.org/10.1007/978-3-540-29676-8_414
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-67136-7
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