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Pancreatic Cancer

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Encyclopedia of Molecular Mechanisms of Disease

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Synonyms

Exocrine pancreatic cancer; Pancreatic carcinoma; Pancreatic adenocarcinoma

Definition and Characteristics

Includes cancers of the exocrine pancreas, excluding tumors derived from the pancreatic islets. Pancreatic cancer has an extremely poor prognosis, with mortality rates nearly matching incidence rates [1]. Incidence is rare before age 45, but increases steadily thereafter. The majority of patients have regional or distant spread at diagnosis. Risk factors include cigarette smoking, diabetes mellitus, obesity, and chronic pancreatitis. Multiple hereditary syndromes increase the risk for pancreatic cancer as well, including hereditary chronic pancreatitis, Peutz-Jeghers syndrome, BRCA2, ataxia-telangectasia, and familial atypical multiple-mole melanoma (FAMMM) [1]. Patients with hereditary pancreatic cancer develop pancreatic cancer earlier in life compared to sporadic cases.

Prevalence

232,241 new cases and 226,949 deaths yearly worldwide [2].

Genes

Multiple genetic...

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References

  1. Li D, Xie K, Wolff R, Abbruzzese JL (2004) Lancet 363:1049–1057

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  5. Lockhart AC, Rothenberg ML, Berlin JD (2005) Gastroenterology 128:1642–1654

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Author information

Authors and Affiliations

  1. Medicine, Pharmacology and Cancer Biology, Duke University, Durham, NC, USA

    Stephan DiSean Kendall & Gerard C. Blobe

Authors
  1. Stephan DiSean Kendall
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  2. Gerard C. Blobe
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Editor information

Editors and Affiliations

  1. Institute of Physiology, University of Tuebingen, Tuebingen, Germany

    Florian Lang (Prof.) (Prof.)

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© 2009 Springer-Verlag GmbH Berlin Heidelberg

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Kendall, S.D., Blobe, G.C. (2009). Pancreatic Cancer. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_3272

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