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Bullous Emphysema

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Synonyms

Bullous lung disease; Lung bullae

Definition and Characteristics

Bullous emphysema (BE) is defined as a form of emphysema characterized by the presence of bullae, which are well-delimited air spaces with walls not more than 1-mm thick. In most cases, BE is a part of widespread diffuse (nonbullous) emphysema (DE).

Prevalence

Lung bullae occur in a variety of disorders, most often in association with chronic obstructive pulmonary disease (COPD), especially DE. However, bullae may occur in lungs that are otherwise normal [1]. Consequently, patients with bullous lung disease can be subdivided into those with COPD-associated BE and those without airways obstruction (Primitive bullous disease, PBD). No prevalence studies on this specific form of emphysema are available.

Similar to DE, the main risk factors for the development of BE are tobacco smoke and α1-antitrypsin deficiency. In addition, marijuana and cocaine smoke have been associated with giant BE in young patients with no...

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References

  1. Morgan MDL, Edwards CW, Morris J, Matthews HR (1989) Thorax 44:533–538

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  3. Painter JN, Tapanainen H, Somer M, Tukiainen P, Aittomaki K (2005) Am J Hum Genet 76:522–527

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  4. Mura M, Zompatori M, Mussoni A, Fasano L, Pacilli AMG, Ferro O, Schiavina M, Fabbri M (2005) Respir Med 99:171–178

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  5. Greenberg JA, Singhal S, Kaiser LR (2003) Chest Surg Clin N Am 13:631–649

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© 2009 Springer-Verlag GmbH Berlin Heidelberg

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Mura, M. (2009). Bullous Emphysema. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_260

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