Synonyms
Non-X-histiocytosis; Classification and subgroups: (i) systemic Non-Langerhans'cell histiocytosis (hemophagocytic lymphohistiocytosis, Rosai-Dorfman disease); (ii) cutaneous Non-Langerhans' cell histiocytosis: (i) juvenile xanthogranuloma (juvenile xanthogranuloma sensu strictu, benign cephalic histiocytosis, generalized eruptive histiocytoma of childhood), (ii) adult xanthogranuloma (adult xanthogranuloma sensu strictu, papular xanthoma, generalized eruptive histiocytoma, xanthoma disseminatum, multicentric reticulohistiocytosis, Erdheim-Chester disease), (iii) necrobiotic xanthogranuloma, (iv) spindle cell Non-Langerhans'cell histiocytosis (hereditary progressive mucinous histiocytosis, progressive nodular histiocytosis); N-LCH.
Definition and Characteristics
The systemic form of Non-Langerhans' cell histiocytosis (N-LCH) is regarded as an accumulation of classically activated macrophages (Mφ1). In contrast, the lesions of cutanous N-LCH are caused by alternative activated...
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References
Utikal J et al. (2007) Imatinib as a treatment option for systemic non-Langerhans all histrocytoses. Arch Dematol 143:736–740
Goerdt S et al. (1993) Immunohistochemical comparison of cutaneous histiocytoses and related skin disorders: diagnostic and histogenetic relevance of MS-1 high molecular weight protein expression. J Pathol 170:421–427
Goerdt S, Orfanos CE (1999) Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 10:137–142
Utikal J et al. (2003) Die kutanen Non-Langerhans-Zell-Histiozytosen. JDDG 6:471–491
Zelger BW et al. (1996) Non-Langerhans cell histiocytoses. A new unifying concept. Am J Dermatopathol 18:490–504
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Utikal, J., Gratchev, A., Goerdt, S. (2009). Non-Langerhans' Cell Histiocytoses. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_1296
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DOI: https://doi.org/10.1007/978-3-540-29676-8_1296
Publisher Name: Springer, Berlin, Heidelberg
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