Angiomatous Hamartoma

Synonyms

Eccrine angiomatous hamartoma; EAH; Sudoriparous angiomatous hamartoma; Functioning sudoriparous angiomatous hamartoma; Nevus of the sweat gland; Cavernous angiomatosis of the sweat ducts

Definition and Characteristics

Hamartoma is a non-neoplastic proliferation of cells and tissue components that occurs in an affected area. In its EAH form, there is an increased number of eccrine secretory and ductal elements within the angiomatous channels.

Prevalence

Although adult onset has been reported, the disease is most commonly seen during early childhood. There is no apparent gender preference. EAH is a rare disorder with approximately 50 cases reported in the literature.

Genes

The genetic characteristics have not been demonstrated.

Molecular and Systemic Pathophysiology

EAH is a rare cutaneous hamartoma appearing histologically as a proliferation of eccrine sweat glands with angiomatous vascular elements that are of capillary origin. A deficiency between the mesenchyme and...