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Hormones and Cerebellar Development

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  • First Online:
Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

Cerebellar development and plasticity involve various epigenetic processes that activate specific genes at different time points, including humoral influences from endocrine cells. Of the circulating hormones, a group of small lipophilic hormones including steroids (corticosteroids, progesterone, androgens, and estrogens) and thyroid hormones help mediate environmental influences on the cerebellum. Receptors for such lipophilic hormones are mainly located inside the cell nucleus (nuclear receptor, NR). They represent the largest family of ligand-regulated transcription factors. In the cerebellum, they are expressed in a specific temporal and spatial pattern. Of the lipophilic hormones, the impact of the thyroid hormone and gonadal steroids on cerebellar development has been studied extensively. Thyroid hormone deficiency during postnatal development results in abnormal morphogenesis and functional impairment. Estrogen and progesterone also play important roles in this process. In addition to the supply from circulation, several gonadal steroids are produced locally within the Purkinje cells (neurosteroids). This chapter discusses the effect of thyroid and steroid hormones on cerebellar development. Neurosteroids that are locally synthesized in the cerebellum are discussed in a different chapter.

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Authors and Affiliations

  1. Department of Integrative physiology, Gunma University Graduate School of Medicine, Maebashi, Japan

    Noriyuki Koibuchi

  2. Department of Anatomy, School of Dentistry, Aichi Gakuin University, Nagoya, Japan

    Yayoi Ikeda

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  1. Noriyuki Koibuchi
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  2. Yayoi Ikeda
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Correspondence to Noriyuki Koibuchi .

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Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

  2. Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

  3. Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

  4. Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, TX, USA

    Roy V. Sillitoe

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Koibuchi, N., Ikeda, Y. (2020). Hormones and Cerebellar Development. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_16-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_16-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-97911-3

  • Online ISBN: 978-3-319-97911-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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