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Drug Delivery: Localized and Systemic Therapeutic Strategies with Polymer Systems

  • Living reference work entry
  • First Online:
Functional Polymers

Part of the book series: Polymers and Polymeric Composites: A Reference Series ((POPOC))

Abstract

This chapter expands upon some of the basic concepts regarding drug delivery and takes a tour through various regions of the body that are commonly treated locally with controlled release systems, investigating current research and commercial strategies involving the use of polymeric systems within each region after briefly describing the biology and the typical biological targets of each region. This section includes drug delivery throughout the gastrointestinal tract and to the skin, lungs, brain, and eye, along with several others. The use of polymeric materials for systemic controlled release is then briefly described and thoroughly investigated in a case study on the most common target of systemically delivered nanomedicines: cancer. The chapter concludes with a perspective on where the field of drug delivery is headed in the future.

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Abbreviations

AMD:

Age-related macular degeneration

AMF:

Alternating magnetic field

AMT:

Adsorptive-mediated transcytosis

APC:

Antigen-presenting cells

BA:

Bioavailability

BBB:

Blood-brain barrier

BCNU:

1,3-bis(2-Chloroethyl)-1-nitrosourea

BRB:

Blood-retinal barrier

CNS:

Central nervous system

COPD:

Chronic obstructive pulmonary disease

CPT:

Camptothecin

DNA:

Deoxyribonucleic acid

Dox:

Doxorubicin

DSPE:

Distearoylphosphatidylethanolamine

EGF:

Epidermal growth factor

EPR:

Enhanced permeability and retention

EVA:

Ethylene vinyl acetate

F(ab′)2:

Dimers of Fabs

Fab:

Antigen-binding fragments

FDA:

U.S. Food and Drug Administration

FGF:

Fibroblast growth factor

GI:

Gastrointestinal

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

HA:

Hyaluronic acid

HGH:

Human growth hormone

HIV:

Human immunodeficiency virus

HPV:

Human papillomavirus

IGF-1:

Insulin-like growth factor

IgG:

Immunoglobulin G

IR:

Infrared

LbL:

Layer-by-layer

LCST:

Lower critical solution temperature

LRP:

Low-density lipoprotein receptor-related protein

MPEG:

Methyl ether poly(ethylene glycol)

MPS:

Mononuclear phagocyte system

MRI:

Magnetic resonance imaging

NCS:

Nanotoxicological classification system

NIPAM:

N-Isopropyl acrylamide

PAMAM:

Polyamidoamine

PBA:

Phenyl boronic acid

PBAE:

Poly(β-amino ester)

PCL:

Polycaprolactone

PDGF:

Platelet-derived growth factor

PDMS:

Polydimethylsiloxane

PEG:

Poly(ethylene glycol)

PEI:

Poly(ethylene imine)

PEM:

Polyelectrolyte multilayers

PEO:

Poly(ethylene oxide)

PHEMA:

Poly(2-hydroxyethyl methacrylate)

PLGA:

Poly(lactic acid-co-glycolic acid)

PMMA:

poly(methyl methacrylate)

PNIPAM:

Poly(N-isopropyl acrylamide)

POEGMA:

Poly(oligoethylene glycol methacrylate)

PPO:

Poly(propylene oxide)

Ptx:

Paclitaxel

PVA:

Polyvinyl alcohol

RGD:

Arginine-glycine-aspartic acid

RNA:

Ribonucleic acid

SC:

Subcutaneous

scFv:

Single-chain fragment variables

siRNA:

Small-interfering RNA

SPIONs:

Superparamagnetic iron oxide nanoparticles

Tg:

Glass transition temperature

TGF-β1:

Transforming growth factor

UV:

Ultraviolet

VPPT:

Volume phase transition temperature

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  1. Department of Chemical Engineering, McMaster University, Hamilton, ON, Canada

    Scott Campbell

  2. EcoSynthetix, Burlington, ON, Canada

    Niels Smeets

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  1. Minerals, King Fahd University of Petroleum a, Dhahran, Saudi Arabia

    Mohammad Abu Jafar Mazumder

  2. McMaster University, Hamilton, ON, Canada

    Heather Sheardown

  3. Minerals, King Fahd University of Petroleum a, Dhahran, Saudi Arabia

    Amir Al-Ahmed

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Campbell, S., Smeets, N. (2019). Drug Delivery: Localized and Systemic Therapeutic Strategies with Polymer Systems. In: Jafar Mazumder, M., Sheardown, H., Al-Ahmed, A. (eds) Functional Polymers. Polymers and Polymeric Composites: A Reference Series. Springer, Cham. https://doi.org/10.1007/978-3-319-92067-2_32-1

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