Abstract
In recent years, growing attention has been focused on the use of natural sources of antioxidants in the prevention of chronic diseases. Flavonoids are the examples of such substances. It is a group of bioactive compounds that are widely distributed in many plant-based foods and beverages. Flavonoid-rich products include, among others, berries, citrus fruits, grapes, cherries, dock, arugula, onions, artichokes, soybeans, cowpeas, black beans, parsley, oregano, and tea. Flavonoids exhibit a wide range of positive effects, such as strong antioxidant, anti-inflammatory, and antiplatelet activities. They may contribute to the prevention of chronic diseases, including metabolic disorders, diabetes, and cardiovascular disease, because of their beneficial effect on blood lipids, blood pressure, plasma glucose levels, and also stabilization of athetosclerotic plaque. Furthermore, evidence from epidemiological, animal, and in vitro studies support protective effects of foods and dietary supplements rich in flavonoids against some types of cancer, Alzheimer’s disease, Parkinson’s disease, some viral infections, cataract, erectile dysfunction, and inflammatory bowel disease. Consumption of flavonoids with diet appears to be safe. There is a growing body of evidence that a diet rich in these substances is beneficial for health and its promotion is thus justifiable.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Middleton E Jr (1998) Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol 439:175–182
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Scientific World Journal 2013:162750
Kozłowska A, Szostak-Węgierek D (2014) Flavonoids-food sources and health benefits. Rocz Panstw Zakl Hig 65:79–85
Pollastri S, Tattini M (2011) Flavonols: old compounds for old roles. Ann Bot 108:1225–1233
Csepregi K, Neugart S, Schreiner M, Hideg E (2016) Comparative evaluation of total antioxidant capacities of plant polyphenols. Molecules 21:28
Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J Nutr Sci 5:e47. https://doi.org/10.1017/jns.2016.41
Bhagwat S, Haytowits DB, Holden JM (2013) USDA Database for the flavonoid content of selected foods. Release 3.1. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center Agricultural Research Service U.S. Department of Agriculture, 1–155
Zakaryan H, Arabyan E, Oo A, Zandi K (2017) Flavonoids: promising natural compounds against viral infections. Arch Virol 162:2539–2551. https://doi.org/10.1007/s00705-017-3417-y
Bhaswant M, Fanning K, Netzel M, Mathai ML, Panchal SK, Brown L (2015) Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats. Pharmacol Res 102:208–217
Kim K, Vance TM, Chun OK (2016) Estimated intake and major food sources of flavonoids among US adults: changes between 1999–2002 and 2007–2010 in NHANES. Eur J Nutr 55:833–843
Witkowska AM, Zujko ME, Waskiewicz A, Terlikowska KM, Piotrowski W (2015) Comparison of various databases for estimation of dietary polyphenol intake in the population of Polish adults. Forum Nutr 7:9299–9308
Kozłowska A, Przekop D, Szostak-Węgierek D (2015) Flavonoids intake among Polish and Spanish students. Rocz Panstw Zakl Hig 66(4):319–325
Wang Y, Qian J, Cao J, Wang D, Liu C, Yang R, Li X, Sun C (2017) Antioxidant capacity, anticancer ability and flavonoids composition of 35 citrus (Citrus reticulata Blanco) varieties. Molecules 22:–114. https://doi.org/10.3390/molecules22071114
Wen L, Zhao Y, Jiang Y, Yu L, Zeng X, Yang J, Tian M, Liu H, Yang B (2017) Identification of a flavonoid C-glycoside as potent antioxidant. Free Radic Biol Med 110:92–101
Wen L, Jiang Y, Yang J, Zhao Y, Tian M, Yang B (2017) Structure, bioactivity, and synthesis of methylated flavonoids. Ann N Y Acad Sci 1398:120–129
Marunaka Y (2017) Actions of quercetin, a flavonoid, on ion transporters: its physiological roles. Ann N Y Acad Sci 1398:142–151
Jurikova T, Mlcek J, Skrovankova S, Sumczynski D, Sochor J, Hlavacova I, Snopek L, Orsavova J (2017) Fruits of Black Chokeberry Aronia melanocarpa in the prevention of chronic diseases. Molecules 22. https://doi.org/10.3390/molecules22060944
Majewska-Wierzbicka M, Czeczot H (2012) Flavonoids in the prevention and treatment of cardiovascular diseases. Pol Merkur Lekarski 32:50–54
Faggio C, Sureda A, Morabito S, Sanches-Silva A, Mocan A, Nabavi SF, Nabavi SM (2017) Flavonoids and platelet aggregation: a brief review. Eur J Pharmacol 807:91–101
Lin SH, Huang KJ, Weng CF, Shiuan D (2015) Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening. Drug Des Devel Ther 9:3313–3324
Li D, Zhang Y, Liu Y, Sun R, Xia M (2015) Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. J Nutr 145:742–748
Zhu Y, Huang X, Zhang Y, Wang Y, Liu Y, Sun R, Xia M (2014) Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia. J Clin Endocrinol Metab 99:561–569
Kianbakht S, Abasi B, Hashem Dabaghian F (2014) Improved lipid profile in hyperlipidemic patients taking Vaccinium arctostaphylos fruit hydroalcoholic extract: a randomized double-blind placebo-controlled clinical trial. Phytother Res 28:432–436
Cassidy A, Bertoia M, Chiuve S, Flint A, Forman J, Rimm EB (2016) Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men. Am J Clin Nutr 104:587–594
Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB (2013) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 127: 188–196
McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT (2012) Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 95:454–464
Goetz ME, Judd SE, Safford MM, Hartman TJ, McClellan WM, Vaccarino V (2016) Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Am J Clin Nutr 104:1236–1244
Jacques PF, Cassidy A, Rogers G, Peterson JJ, Dwyer JT (2015) Dietary flavonoid intakes and CVD incidence in the Framingham Offspring Cohort. Br J Nutr 114:1496–1503
Matsuyama T, Tanaka Y, Kamimaki I, Nagao T, Tokimitsu I (2008) Catechin safely improved higher levels of fatness, blood pressure, and cholesterol in children. Obesity (Silver Spring) 16:1338–1348
Li B, Yang M, Liu JW, Yin GT (2016) Protective mechanism of quercetin on acute myocardial infarction in rats. Genet Mol Res 15:15017117. https://doi.org/10.4238/gmr.15017117
Brull V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Muller C, Langguth P, Alteheld B, Fimmers R, Naaf S, Zimmermann BF, Stehle P, Egert S (2015) Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br J Nutr 114:1263–1277
Larson AJ, Symons JD, Jalili T (2012) Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr 3:39–46
Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, Botting NP, Kay CD (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study. Am J Clin Nutr 97:995–1003
Cassidy A (2017) Berry anthocyanin intake and cardiovascular health. Mol Asp Med. https://doi.org/10.1016/j.mam.2017.05.002
Cassidy A, Minihane AM (2017) The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids. Am J Clin Nutr 105:10–22
Babu PVA, Liu D, Gilbert ER (2013) Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem 24:1777–1789
Liu Y-J, Zhan J, Liu X-L, Wang Y, Ji J, He Q-Q (2014) Dietary flavonoids intake and risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Clin Nutr 33:59–63
Tresserra-Rimbau A, Guasch-Ferre M, Salas-Salvado J, Toledo E, Corella D, Castaner O, Guo X, Gomez-Gracia E, Lapetra J, Aros F, Fiol M, Ros E, Serra-Majem L, Pinto X, Fito M, Babio N, Martinez-Gonzalez MA, Sorli JV, Lopez-Sabater MC, Estruch R, Lamuela-Raventos RM (2016) Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly people at high cardiovascular disease risk. J Nutr 146:767. https://doi.org/10.3945/jn.115.223610
Liu Y, Li J, Wang T, Wang Y, Zhao L, Fang Y (2017) The effect of genistein on glucose control and insulin sensitivity in postmenopausal women: a meta-analysis. Maturitas 97:44–52
de Koning Gans JM, Uiterwaal CS, van der Schouw YT, Boer JM, Grobbee DE, Verschuren WM, Beulens JW (2010) Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol 30:1665–1671
Wallace TC, Slavin M, Frankenfeld CL (2016) Systematic review of anthocyanins and markers of cardiovascular disease. Forum Nutr 8. https://doi.org/10.3390/nu8010032
JS O, Kim H, Vijayakumar A, Kwon O, Choi YJ, Huh KB, Chang N (2016) Association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome in Korean women with type 2 diabetes mellitus. Nutr Res Pract 10:67–73
Schloesser A, Esatbeyoglu T, Schultheiss G, Vollert H, Luersen K, Fischer A, Rimbach G (2017) Antidiabetic properties of an apple/kale extract in vitro, in situ, and in mice fed a Western-type diet. J Med Food 20:846–854. https://doi.org/10.1089/jmf.2017.0019
Assini JM, Mulvihill EE, Burke AC, Sutherland BG, Telford DE, Chhoker SS, Sawyez CG, Drangova M, Adams AC, Kharitonenkov A, Pin CL, Huff MW (2015) Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21. Endocrinology 156:2087–2102
Priscilla DH, Roy D, Suresh A, Kumar V, Thirumurugan K (2014) Naringenin inhibits α-glucosidase activity: a promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats. Chem Biol Interact 210:77–85
Jennings A, Welch AA, Spector T, Macgregor A, Cassidy A (2014) Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr 144:202–208
Chahar MK, Sharma N, Dobhal MP, Joshi YC (2011) Flavonoids: a versatile source of anticancer drugs. Pharmacogn Rev 5:1–12
Liao W, Chen L, Ma X, Jiao R, Li X, Wang Y (2016) Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells. Eur J Med Chem 114:24–32
LY T, Bai HH, Cai JY, Deng SP (2016) The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: from macro to nano. Scanning 38:644–653. https://doi.org/10.1002/sca.21312
Chen HJ, Lin CM, Lee CY, Shih NC, Peng SF, Tsuzuki M, Amagaya S, Huang WW, Yang JS (2013) Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncol Rep 30:925–932
Kim SH, Hwang KA, Choi KC (2016) Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J Nutr Biochem 28:70–82
Qin Y, Cui W, Yang X, Tong B (2016) Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim Biophys Sin Shanghai 48:238–245
Dang Q, Song W, Xu D, Ma Y, Li F, Zeng J, Zhu G, Wang X, Chang LS, He D, Li L (2015) Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis. Mol Carcinog 54:831–840
Li C, Zhao Y, Yang D, Yu Y, Guo H, Zhao Z, Zhang B, Yin X (2015) Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Biochem Cell Biol 93:16–27
Katiyar SK (2016) Emerging phytochemicals for the prevention and treatment of head and neck cancer. Molecules 21. https://doi.org/10.3390/molecules21121610
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90
Xie Q, Chen ML, Qin Y, Zhang QY, HX X, Zhou Y, Mi MT, Zhu JD (2013) Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies. Asia Pac J Clin Nutr 22:118–127
Wada K, Nakamura K, Tamai Y, Tsuji M, Kawachi T, Hori A, Takeyama N, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C (2013) Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study. Int J Cancer 133:952–960
Hua X, Yu L, You R, Yang Y, Liao J, Chen D, Yu L (2016) Association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk: a meta-analysis. PLoS One 11:e0151134. https://doi.org/10.1371/journal.pone.0151134
Woo HD, Kim J (2013) Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PLoS One 8:e75604. https://doi.org/10.1371/journal.pone.0075604
Guo Y, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X (2017) Green tea and the risk of prostate cancer: a systematic review and meta-analysis. Medicine (Baltimore) 96:e6426. https://doi.org/10.1097/md.0000000000006426
Grosso G, Godos J, Lamuela-Raventos R, Ray S, Micek A, Pajak A, Sciacca S, D'Orazio N, Del Rio D, Galvano F (2017) A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: level of evidence and limitations. Mol Nutr Food Res 61. https://doi.org/10.1002/mnfr.201600930
Amawi H, Ashby CR Jr, Tiwari AK (2017) Cancer chemoprevention through dietary flavonoids: what’s limiting? Chin J Cancer 36:50. https://doi.org/10.1186/s40880-017-0217-4
Xin LT, Liu L, Shao CL, Yu RL, Chen FL, Yue SJ, Wang M, Guo ZL, Fan YC, Guan HS, Wang CY (2017) Discovery of DNA topoisomerase I inhibitors with low-cytotoxicity based on virtual screening from natural products. Mar Drugs 15. https://doi.org/10.3390/md15070217
Jablonska-Trypuc A, Matejczyk M, Rosochacki S (2016) Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs. J Enzyme Inhib Med Chem 1:7
George VC, Rupasinghe HPV (2017) Apple flavonoids suppress carcinogen-induced DNA damage in normal human bronchial epithelial cells. Oxidative Med Cell Longev 2017:1767198. https://doi.org/10.1155/2017/1767198
Russo M, Russo GL, Daglia M, Kasi PD, Ravi S, Nabavi SF, Nabavi SM (2016) Understanding genistein in cancer: the “good” and the “bad” effects: a review. Food Chem 196:589–600
Jiang Y, Gong P, Madak-Erdogan Z, Martin T, Jeyakumar M, Carlson K, Khan I, Smillie TJ, Chittiboyina AG, Rotte SC, Helferich WG, Katzenellenbogen JA, Katzenellenbogen BS (2013) Mechanisms enforcing the estrogen receptor beta selectivity of botanical estrogens. FASEB J 27:4406–4418
Seo HS, Choi HS, Choi HS, Choi YK, Um JY, Choi I, Shin YC, Ko SG (2011) Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells. Anticancer Res 31:3301–3313
Prietsch RF, Monte LG, da Silva FA, Beira FT, Del Pino FA, Campos VF, Collares T, Pinto LS, Spanevello RM, Gamaro GD, Braganhol E (2014) Genistein induces apoptosis and autophagy in human breast MCF-7 cells by modulating the expression of proapoptotic factors and oxidative stress enzymes. Mol Cell Biochem 390:235–242
Shike M, Doane AS, Russo L, Cabal R, Reis-Filho JS, Gerald W, Cody H, Khanin R, Bromberg J, Norton L (2014) The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study. J Natl Cancer Inst. 106. https://doi.org/10.1093/jnci/dju189
Bircsak KM, Aleksunes LM (2015) Interaction of isoflavones with the BCRP/ABCG2 drug transporter. Curr Drug Metab 16:124–140
Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P (2007) Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 165:1364–1371
Calsolaro V, Edison P (2016) Neuroinflammation in Alzheimer’s disease: current evidence and future directions. Alzheimers Dement 12:719–732
Tramutola A, Lanzillotta C, Perluigi M, Butterfield DA (2016) Oxidative stress, protein modification and Alzheimer disease. Brain Res Bull 133:88–96. https://doi.org/10.1016/j.brainresbull.2016.06.005
Magalingam KB, Radhakrishnan AK, Haleagrahara N (2015) Protective mechanisms of flavonoids in Parkinson’s disease. Oxidative Med Cell Longev 2015:314560
Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3:115–126
Solanki I, Parihar P, Mansuri ML, Parihar MS (2015) Flavonoid-based therapies in the early management of neurodegenerative diseases. Adv Nutr 6:64–72
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT (2011) Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 1:a006189. https://doi.org/10.1101/cshperspect.a006189
Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H (2008) Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta 1780:819–825
Dragicevic N, Smith A, Lin X, Yuan F, Copes N, Delic V, Tan J, Cao C, Shytle RD, Bradshaw PC (2011) Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer’s amyloid-induced mitochondrial dysfunction. J Alzheimers Dis 26:507–521
Fernando W, Somaratne G, Goozee KG, Williams S, Singh H, Martins RN (2017) Diabetes and Alzheimer’s disease: can tea phytochemicals play a role in prevention? J Alzheimers Dis 59:481–501. https://doi.org/10.3233/jad-161200
Xicota L, Rodriguez-Morato J, Dierssen M, de la Torre R (2017) Potential role of (−)-Epigallocatechin-3-Gallate (EGCG) in the secondary prevention of Alzheimer disease. Curr Drug Targets 18:174–195
Chesser AS, Ganeshan V, Yang J, Johnson GV (2016) Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci 19:21–31
Magalingam KB, Radhakrishnan A, Haleagrahara N (2013) Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Int J Mol Med 32:235–240
Magalingam KB, Radhakrishnan A, Haleagrahara N (2014) Protective effects of flavonol isoquercitrin, against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells. BMC Res Notes 7:49
Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT (2001) Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson’s disease. Neuroreport 12:3871–3875
Gao X, Cassidy A, Schwarzschild MA, Rimm EB, Ascherio A (2012) Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology 78:1138–1145
Socci V, Tempesta D, Desideri G, De Gennaro L, Ferrara M (2017) Enhancing human cognition with cocoa flavonoids. Front Nutr 4:19
Mastroiacovo D, Kwik-Uribe C, Grassi D, Necozione S, Raffaele A, Pistacchio L, Righetti R, Bocale R, Lechiara MC, Marini C, Ferri C, Desideri G (2015) Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial. Am J Clin Nutr 101:538–548
Samieri C, Sun Q, Townsend MK, Rimm EB, Grodstein F (2014) Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr 100:1489–1497
Eleazu C, Obianuju N, Eleazu K, Kalu W (2017) The role of dietary polyphenols in the management of erectile dysfunction-mechanisms of action. Biomed Pharmacother 88:644–652
Pavan V, Mucignat-Caretta C, Redaelli M, Ribaudo G, Zagotto G (2015) The old made new: natural compounds against erectile dysfunction. Arch Pharm (Weinheim) 348:607–614
Oboh G, Ademiluyi AO, Ademosun AO, Olasehinde TA, Oyeleye SI, Boligon AA, Athayde ML (2015) Phenolic extract from Moringa oleifera leaves inhibits key enzymes linked to erectile dysfunction and oxidative stress in rats’ penile tissues. Biochem Res Int 2015:175950
Cassidy A, Franz M, Rimm EB (2016) Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr 103:534–541
Patil KK, Gacche RN (2017) Inhibition of glycation and aldose reductase activity using dietary flavonoids: a lens organ culture studies. Int J Biol Macromol 98:730–738
Patel DK, Prasad SK, Kumar R, Hemalatha S (2011) Cataract: a major secondary complication of diabetes, its epidemiology and an overview on major medicinal plants screened for anticataract activity. Asian Pac J Trop Dis 1:323–329
Bhatnagar A, Srivastava SK (1992) Aldose reductase: congenial and injurious profiles of an enigmatic enzyme. Biochem Med Metab Biol 48:91–121
Patil KK, Meshram RJ, Dhole NA, Gacche RN (2016) Role of dietary flavonoids in amelioration of sugar induced cataractogenesis. Arch Biochem Biophys 593:1–11
Mok JW, Chang DJ, Joo CK (2014) Antiapoptotic effects of anthocyanin from the seed coat of black soybean against oxidative damage of human lens epithelial cell induced by H2O2. Curr Eye Res 39:1090–1098
Chantrill BH, Coulthard CE, Dickinson L, Inkley GW, Mrris W, Pyle AH (1952) The action of plant extracts on a bacteriophage of pseudomonas pyocyanea and on influenza a virus. Microbiology 6:74–84
Li B, Guo QL, Tian Y, Liu SJ, Wang Q, Chen L, Dong JX (2016) New anti-HBV C-boivinopyranosyl flavones from Alternanthera philoxeroides. Molecules 21. https://doi.org/10.3390/molecules21030336
He W, Li LX, Liao QJ, Liu CL, Chen XL (2011) Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication – inducible cell line. World J Gastroenterol 17:1507–1514
Zhong L, Hu J, Shu W, Gao B, Xiong S (2015) Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication. Cell Death Dis 6:e1770. https://doi.org/10.1038/cddis.2015.136
Behbahani M, Sayedipour S, Pourazar A, Shanehsazzadeh M (2014) In vitro anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca. Res Pharm Sci 9:463–469
Liang G, Li N, Ma L, Qian Z, Sun Y, Shi L, Zhao L (2016) Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo. Acta Pharma 66:97–107
Cantatore A, Randall SD, Traum D, Adams SD (2013) Effect of black tea extract on herpes simplex virus-1 infection of cultured cells. BMC Complement Altern Med 13:139
de Oliveira A, Adams SD, Lee LH, Murray SR, Hsu SD, Hammond JR, Dickinson D, Chen P, Chu TC (2013) Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate. Food Chem Toxicol 52:207–215
Liang W, He L, Ning P, Lin J, Li H, Lin Z, Kang K, Zhang Y (2015) (+)-Catechin inhibition of transmissible gastroenteritis coronavirus in swine testicular cells is involved its antioxidation. Res Vet Sci 103:28–33
Muller P, Downard KM (2015) Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry. J Pharm Biomed Anal 111:222–230
Isaacs CE, Xu W, Merz G, Hillier S, Rohan L, Wen GY (2011) Digallate dimers of (−)-epigallocatechin gallate inactivate herpes simplex virus. Antimicrob Agents Chemother 55:5646–5653
Hung PY, Ho BC, Lee SY, Chang SY, Kao CL, Lee SS, Lee CN (2015) Houttuynia cordata targets the beginning stage of herpes simplex virus infection. PLoS One 10:e0115475. https://doi.org/10.1371/journal.pone.0115475
Li J, Liu Y, Wang Z, Liu K, Wang Y, Liu J, Ding H, Yuan Z (2011) Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. J Virol 85:6319–6333
Liu SH, Lu TH, Su CC, Lay IS, Lin HY, Fang KM, Ho TJ, Chen KL, Su YC, Chiang WC, Chen YW (2014) Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via JNK/NF-kappaB signaling pathway. Am J Chin Med 42:869–889
Fan FY, Sang LX, Jiang M (2017) Catechins and their therapeutic benefits to inflammatory bowel disease. Molecules 22. https://doi.org/10.3390/molecules22030484
Bruckner M, Westphal S, Domschke W, Kucharzik T, Lugering A (2012) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis. J Crohns Colitis 6:226–235
Vasconcelos PC, Seito LN, Di Stasi LC, Akiko Hiruma-Lima C, Pellizzon CH (2012) Epicatechin used in the treatment of intestinal inflammatory disease: an analysis by experimental models. Evid Based Complement Alternat Med 2012:508902. https://doi.org/10.1155/2012/508902
Chen XQ, Hu T, Han Y, Huang W, Yuan HB, Zhang YT, Du Y, Jiang YW (2016) Preventive effects of catechins on cardiovascular disease. Molecules 21. https://doi.org/10.3390/molecules21121759
Chiou YS, Huang Q, Ho CT, Wang YJ, Pan MH (2016) Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (−)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia. Free Radic Biol Med 94:1–16
Na HK, Surh YJ (2008) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol 46:1271–1278
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this entry
Cite this entry
Kozłowska, A., Szostak-Węgierek, D. (2019). Flavonoids – Food Sources, Health Benefits, and Mechanisms Involved. In: Mérillon, JM., Ramawat, K.G. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-78030-6_54
Download citation
DOI: https://doi.org/10.1007/978-3-319-78030-6_54
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-78029-0
Online ISBN: 978-3-319-78030-6
eBook Packages: Chemistry and Materials ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics