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Soft and Hard Tissue Operative Investigations in the Diagnosis and Treatment of Oral Disease

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Contemporary Oral Medicine

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Abstract

Specialists in oral medicine frequently carry out interventional procedures in the oral cavity. These procedures are usually for diagnostic purposes, but in many instances oral medicine specialists also undertake minor oral surgical procedures as definitive treatment for either mucosal, soft tissue, or hard tissue lesions. This chapter provides an overview of the most common diagnostic procedures used in the oral cavity including soft and hard tissue biopsies. Ancillary techniques such as fine needle aspiration biopsy, the use of fluorescence, toluidine blue, cryotherapy, and lasers are also discussed. Biopsy technique, indications, and pitfalls in addition to medicolegal considerations are covered.

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References

  • Alkan A, Etoz OA. A new anatomical landmark to simplify temporomandibular joint arthrocentesis. Br J Oral Maxillofac Surg. 2010;48(4):310–1.

    Article  PubMed  Google Scholar 

  • Baghani Z, Kadkhodazadeh M. Periodontal dressing: a review article. J Dent Res Dent Clin Dent Prospects. 2013;7(4):183–91.

    PubMed  PubMed Central  Google Scholar 

  • Balasubramaniam AM, Sriraman R, Sindhuja P, Mohideen K, Parameswar RA, Muhamed Haris KT. Autofluorescence based diagnostic techniques for oral cancer. J Pharm Bioallied Sci. 2015;7(Suppl 2):S374–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bankfalvi A, Piffko J. Prognostic and predictive factors in oral cancer: the role of the invasive tumour front. J Oral Pathol Med. 2000;29(7):291–8.

    Article  PubMed  Google Scholar 

  • Baurmash HD. Mucoceles and ranulas. J Oral Maxillofac Surg. 2003;61(3):369–78.

    Article  PubMed  Google Scholar 

  • Baust JG, Gage AA. The molecular basis of cryosurgery. BJU Int. 2005;95(9):1187–91.

    Article  PubMed  Google Scholar 

  • Belcher JM. A perspective on periodontal microsurgery. Int J Periodontics Restorative Dent. 2001;21(2):191–6.

    PubMed  Google Scholar 

  • Bhatia N, Matias MA, Farah CS. Assessment of a decision making protocol to improve the efficacy of VELscopeâ„¢ in general dental practice: a prospective evaluation. Oral Oncol. 2014;50(10):1012–9

    Article  PubMed  Google Scholar 

  • Bornstein MM, Winzap-Kalin C, Cochran DL, Buser D. The CO2 laser for excisional biopsies of oral lesions: a case series study. Int J Periodontics Restorative Dent. 2005;25(3):221–9.

    PubMed  Google Scholar 

  • Bouchard C, Goulet JP, El-Ouazzani M, Turgeon AF. Temporomandibular lavage versus nonsurgical treatments for temporomandibular disorders: a systematic review and meta-analysis. J Oral Maxillofac Surg. 2017;75(7):1352–62.

    Article  PubMed  Google Scholar 

  • Brands WG. The standard for the duty to inform patients about risks: from the responsible dentist to the reasonable patient. Br Dent J. 2006;201(4):207–10.

    Article  PubMed  Google Scholar 

  • Brennan PA, Brands MT, Caldwell L, Fonseca FP, Turley N, Foley S, Rahimi S. Surgical specimen handover from the operating theatre to laboratory-can we improve patient safety by learning from aviation and other high-risk organisations? J Oral Pathol Med. 2017;47:117–20.

    Article  PubMed  Google Scholar 

  • Buckmiller LM, Richter GT, Suen JY. Diagnosis and management of hemangiomas and vascular malformations of the head and neck. Oral Dis. 2010;16(5):405–18.

    Article  PubMed  Google Scholar 

  • Cai Y, Wang R, Yang SF, Zhao YF, Zhao JH. Sclerotherapy for the mucoceles of the anterior lingual salivary glands with pingyangmycin. Oral Dis. 2014;20(5):473–6.

    Article  PubMed  Google Scholar 

  • Chen S, Forman M, Sadow PM, August M. The diagnostic accuracy of incisional biopsy in the oral cavity. J Oral Maxillofac Surg. 2016;74(5):959–64.

    Article  PubMed  Google Scholar 

  • Costa JR, Torriani MA, Hosni ES, D'Avila OP, de Figueiredo PJ. Sclerotherapy for vascular malformations in the oral and maxillofacial region: treatment and follow-up of 66 lesions. J Oral Maxillofac Surg. 2011;69(6):e88–92.

    Article  PubMed  Google Scholar 

  • De Veld DC, Witjes MJ, Sterenborg HJ, Roodenburg JL. The status of in vivo autofluorescence spectroscopy and imaging for oral oncology. Oral Oncol. 2005;41(2):117–31.

    Article  PubMed  Google Scholar 

  • Delli K, Spijkervet FK, Vissink A. Salivary gland diseases: infections, sialolithiasis and mucoceles. Monogr Oral Sci. 2014;24:135–48.

    Article  PubMed  Google Scholar 

  • Di Palma S, Simpson R, Skalova A, Leivo I. Major and minor salivary glands. In: Slootweg P, Cardesa A, editors. Pathology of the head and neck. Berlin/Heidelberg: Springer; 2006. p. 132–70.

    Google Scholar 

  • Dieterich-Miller CA, Safford PL. Psychosocial development of children with hemangiomas: home, school, health care collaboration. Child Health Care. 1992;21(2):84–9.

    Article  PubMed  Google Scholar 

  • Dilsiz A, Aydin T, Gursan N. Capillary hemangioma as a rare benign tumor of the oral cavity: a case report. Cases J. 2009;2:8622.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dost F, Do L, Farah CS. Lesion evaluation, screening and identification of oral neoplasia study: an assessment of high-risk Australian populations. Community Dent Oral Epidemiol. 2016;44(1):64–75.

    Article  PubMed  Google Scholar 

  • Dost F, Le Cao KA, Ford PJ, Farah CS. A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):725–33.

    Article  PubMed  Google Scholar 

  • Epstein JB, Oakley C, Millner A, Emerton S, van der Meij E, Le N. The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(5):537–47.

    Article  PubMed  Google Scholar 

  • Epstein JB, Scully C, Spinelli J. Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J Oral Pathol Med. 1992;21(4):160–3.

    Article  PubMed  Google Scholar 

  • Farah CS. Narrow band imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival. Oral Dis. 2018;24(1–2):89–97.

    Article  PubMed  Google Scholar 

  • Farah CS, Dalley AJ, Nguyen P, Batstone M, Kordbacheh F, Perry-Keene J, Fielding D. Improved surgical margin definition by narrow band imaging for resection of oral squamous cell carcinoma: a prospective gene expression profiling study. Head Neck. 2016;38(6):832–9.

    Article  PubMed  Google Scholar 

  • Farah CS, Fox SA, Dalley AJ. Integrated miRNA-mRNA spatial signature for oral squamous cell carcinoma: a prospective profiling study of narrow band imaging guided resection. Sci Rep. 2018;8(1):823.

    Article  PubMed  PubMed Central  Google Scholar 

  • Farah CS, Kordbacheh F, John K, Bennett N, Fox SA. Molecular classification of autofluorescence excision margins in oral potentially malignant disorders. Oral Dis. 2018;24(5):732–740.

    Article  PubMed  Google Scholar 

  • Farah CS, McIntosh L, Georgiou A, McCullough MJ. Efficacy of tissue autofluorescence imaging (VELScope) in the visualization of oral mucosal lesions. Head Neck. 2012;34(6):856–62.

    Article  PubMed  Google Scholar 

  • Farah CS, Savage NW. Cryotherapy for treatment of oral lesions. Aust Dent J. 2006;51(1):2–5.

    Article  PubMed  Google Scholar 

  • Fischer EG. To fix or not to fix: Michel's is the solution. Int J Surg Pathol. 2006;14(1):108.

    Article  PubMed  Google Scholar 

  • Forman MS, Chuang SK, August M. The accuracy of clinical diagnosis of oral lesions and patient-specific risk factors that affect diagnosis. J Oral Maxillofac Surg. 2015;73(10):1932–7.

    Article  PubMed  Google Scholar 

  • Fuller C, Camilon R, Nguyen S, Jennings J, Day T, Gillespie MB. Adjunctive diagnostic techniques for oral lesions of unknown malignant potential: systematic review with meta-analysis. Head Neck. 2015;37(5):755–62.

    Article  PubMed  Google Scholar 

  • Gage AA, Baust J. Mechanisms of tissue injury in cryosurgery. Cryobiology. 1998;37(3):171–86.

    Article  PubMed  Google Scholar 

  • Gandolfo S, Pentenero M, Broccoletti R, Pagano M, Carrozzo M, Scully C. Toluidine blue uptake in potentially malignant oral lesions in vivo: clinical and histological assessment. Oral Oncol. 2006;42(1):89–95.

    Article  PubMed  Google Scholar 

  • Garg A, Tripathi A, Chowdhry S, Sharma A, Biswas G. Cryosurgery: painless and fearless management of mucocele in young patient. J Clin Diagn Res. 2014;8(8):ZD04–6.

    PubMed  PubMed Central  Google Scholar 

  • Guarda-Nardini L, Manfredini D, Ferronato G. Arthrocentesis of the temporomandibular joint: a proposal for a single-needle technique. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):483–6.

    Article  PubMed  Google Scholar 

  • Gupta A, Singh M, Ibrahim R, Mehrotra R. Utility of toluidine blue staining and brush biopsy in precancerous and cancerous oral lesions. Acta Cytol. 2007;51(5):788–94.

    Article  PubMed  Google Scholar 

  • Hedge MC, Kamath PM, Shreedharan S, Dannana NK, Raju RM. Supravital staining: It's role in detecting early malignancies. Indian J Otolaryngol Head Neck Surg. 2006;58(1):31–4.

    PubMed  PubMed Central  Google Scholar 

  • Horbach SE, Rigter IM, Smitt JH, Reekers JA, Spuls PI, van der Horst CM. Intralesional bleomycin injections for vascular malformations: a systematic review and meta-analysis. Plast Reconstr Surg. 2016;137(1):244–56.

    Article  PubMed  Google Scholar 

  • Iro H, Zenk J, Escudier MP, Nahlieli O, Capaccio P, Katz P, Brown J, McGurk M. Outcome of minimally invasive management of salivary calculi in 4,691 patients. Laryngoscope. 2009;119(2):263–8.

    Article  PubMed  Google Scholar 

  • James K, Toner M, Stassen LF. Performing mucosal tissue biopsies in general dental practice. J Ir Dent Assoc. 2011;57(4):203–8.

    PubMed  Google Scholar 

  • Janssen AJ. Informing patients about small risks: a comparative approach. Eur J Health Law. 2006;13(2):159–72.

    Article  PubMed  Google Scholar 

  • Kawczyk-Krupka A, Waskowska J, Raczkowska-Siostrzonek A, Kosciarz-Grzesiok A, Kwiatek S, Straszak D, Latos W, Koszowski R, Sieron A. Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia. Photodiagn Photodyn Ther. 2012;9(2):148–55.

    Article  Google Scholar 

  • Kocer U, Ozdemir R, Tiftikcioglu YO, Karaaslan O. Soft tissue hemangioma formation within a previously excised intraosseous hemangioma site. J Craniofac Surg. 2004;15(1):82–3.

    Article  PubMed  Google Scholar 

  • Kondori I, Mottin RW, Laskin DM. Accuracy of dentists in the clinical diagnosis of oral lesions. Quintessence Int. 2011;42(7):575–7.

    PubMed  Google Scholar 

  • Kujan O, Pemberton MN, Schwarz M, Sloan P. Evaluation of an innovative oral brush for potential applications using liquid based cytology. J Oral Sci. 2018;60(1):45–50.

    Article  PubMed  Google Scholar 

  • Kumaraswamy KL, Vidhya M, Rao PK, Mukunda A. Oral biopsy: oral pathologist’s perspective. J Cancer Res Ther. 2012;8(2):192–8.

    Article  PubMed  Google Scholar 

  • Levy O, Topilski M, Brazowski E, Yaron M, Tishler M. Sarcoidosis presenting as primary Sjogren’s syndrome. Isr Med Assoc J. 2001;3(1):63–4.

    PubMed  Google Scholar 

  • Liboon J, Funkhouser W, Terris DJ. A comparison of mucosal incisions made by scalpel, CO2 laser, electrocautery, and constant-voltage electrocautery. Otolaryngol Head Neck Surg. 1997;116(3):379–85.

    Article  PubMed  Google Scholar 

  • Lingen MW, Kalmar JR, Karrison T, Speight PM. Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol. 2008;44(1):10–22.

    Article  PubMed  Google Scholar 

  • Lynch DP, Morris LF. The oral mucosal punch biopsy: indications and technique. J Am Dent Assoc. 1990;121(1):145–9.

    Article  PubMed  Google Scholar 

  • Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions. Cochrane Database Syst Rev. 2015;5:CD010276.

    Google Scholar 

  • Mashberg A. Reevaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: a continuing prospective study of oral cancer III. Cancer. 1980;46(4):758–63.

    Article  PubMed  Google Scholar 

  • McGurk M, Escudier MP, Brown JE. Modern management of salivary calculi. Br J Surg. 2005;92(1):107–12.

    Article  PubMed  Google Scholar 

  • McIntosh L, McCullough MJ, Farah CS. The assessment of diffused light illumination and acetic acid rinse (Microlux/DL) in the visualisation of oral mucosal lesions. Oral Oncol. 2009;45(12):e227–31.

    Article  PubMed  Google Scholar 

  • Mehrotra R, Hullmann M, Smeets R, Reichert TE, Driemel O. Oral cytology revisited. J Oral Pathol Med. 2009;38(2):161–6.

    Article  PubMed  Google Scholar 

  • Meleti M, Vescovi P, Mooi WJ, van der Waal I. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(5):606–16.

    Article  PubMed  Google Scholar 

  • Melrose RJ, Handlers JP, Kerpel S, Summerlin DJ, Tomich CJ, American Academy of Oral and Maxillofacial Pathology. The use of biopsy in dental practice. The position of the American Academy of oral and maxillofacial pathology. Gen Dent. 2007;55(5):457–61; quiz 462–453, 488

    PubMed  Google Scholar 

  • Mishra M, Singh G, Gaur A, Tandon S, Singh A. Role of sclerotherapy in management of vascular malformation in the maxillofacial region: our experience. Natl J Maxillofac Surg. 2017;8(1):64–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Monje-Gil F, Nitzan D, Gonzalez-Garcia R. Temporomandibular joint arthrocentesis. Review of the literature. Med Oral Patol Oral Cir Bucal. 2012;17(4):e575–81.

    Article  PubMed  PubMed Central  Google Scholar 

  • Moralis A, Kunkel M, Reichert TE, Kosmehl H, Driemel O. Identification of a recurrent oral squamous cell carcinoma by brush cytology. Mund Kiefer Gesichtschir. 2007;11(6):355–8.

    Article  PubMed  Google Scholar 

  • Moule I, Parsons PA, Irvine GH. Avoiding artefacts in oral biopsies: the punch biopsy versus the incisional biopsy. Br J Oral Maxillofac Surg. 1995;33(4):244–7.

    Article  PubMed  Google Scholar 

  • Neeli AS, Umarani M, Kotrashetti SM, Baliga S. Arthrocentesis for the treatment of internal derangement of the temporomandibular joint. J Maxillofac Oral Surg. 2010;9(4):350–4.

    Article  PubMed  Google Scholar 

  • Nelson WJ. Guide to suturing. J Oral Maxillofac Surg. 2015;73(8 Suppl):1–62.

    Article  PubMed  Google Scholar 

  • Odeyinde SO, Kangesu L, Badran M. Sclerotherapy for vascular malformations: complications and a review of techniques to avoid them. J Plast Reconstr Aesthet Surg. 2013;66(2):215–23.

    Article  PubMed  Google Scholar 

  • Oliver RJ, Sloan P, Pemberton MN. Oral biopsies: methods and applications. Br Dent J. 2004;196(6):329–33; quiz 362

    Article  PubMed  Google Scholar 

  • Patel AN, Simpson RC, Cohen SN. In a patient with an immunobullous disorder, is transportation of the skin biopsy in normal saline adequate for direct immunofluorescence analysis? A critically appraised topic. Br J Dermatol. 2013;169(1):6–10.

    Article  PubMed  Google Scholar 

  • Patel KJ, De Silva HL, Tong DC, Love RM. Concordance between clinical and histopathologic diagnoses of oral mucosal lesions. J Oral Maxillofac Surg. 2011;69(1):125–33.

    Article  PubMed  Google Scholar 

  • Pitiyage G, Tilakaratne WM, Tavassoli M, Warnakulasuriya S. Molecular markers in oral epithelial dysplasia: review. J Oral Pathol Med. 2009;38(10):737–52.

    Article  PubMed  Google Scholar 

  • Pogrel MA, McCracken KJ, Daniels TE. Histologic evaluation of the width of soft tissue necrosis adjacent to carbon dioxide laser incisions. Oral Surg Oral Med Oral Pathol. 1990;70(5):564–8.

    Article  PubMed  Google Scholar 

  • Rashid A, Warnakulasuriya S. The use of light-based (optical) detection systems as adjuncts in the detection of oral cancer and oral potentially malignant disorders: a systematic review. J Oral Pathol Med. 2015;44(5):307–28.

    Article  PubMed  Google Scholar 

  • Reibel J. Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med. 2003;14(1):47–62.

    Article  PubMed  Google Scholar 

  • Rezende KM, Moraes Pde C, Oliveira LB, Thomaz LA, Junqueira JL, Bonecker M. Cryosurgery as an effective alternative for treatment of oral lesions in children. Braz Dent J. 2014;25(4):352–6.

    Article  PubMed  Google Scholar 

  • Roodenburg JL, Witjes MJ, de Veld DC, Tan IB, Nauta JM. Lasers in dentistry 8. Use of lasers in oral and maxillofacial surgery. Ned Tijdschr Tandheelkd. 2002;109(12):470–4.

    PubMed  Google Scholar 

  • Sadiq Z, Moss C, Stocker J. Staining from silver nitrate. Br Dent J. 2002;193(6):299.

    Article  PubMed  Google Scholar 

  • Sako K, Marchetta FC, Hayes RL. Cryotherapy of intraoral leukoplakia. Am J Surg. 1972;124(4):482–4.

    Article  PubMed  Google Scholar 

  • Saruhanoglu A, Atikler M, Ergun S, Ofluoglu D, Tanyeri H. Comparison of two different labial salivary gland biopsy incision techniques: a randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2013;18(6):e851–5.

    Article  PubMed  Google Scholar 

  • Schoinohoriti OK, Chrysomali E, Iatrou I, Perrea D. Evaluation of lateral thermal damage and reepithelialization of incisional wounds created by CO2-laser, monopolar electrosurgery, and radiosurgery: a pilot study on porcine oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(6):741–7.

    Article  PubMed  Google Scholar 

  • Sciubba JJ. Improving detection of precancerous and cancerous oral lesions. Computer-assisted analysis of the oral brush biopsy. U.S. Collaborative OralCDx Study Group. J Am Dent Assoc. 1999;130(10):1445–57.

    Article  PubMed  Google Scholar 

  • Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H. Diagnostic accuracy of oral cancer cytology in a pilot study. Diagn Pathol. 2017;12(1):27.

    Article  PubMed  PubMed Central  Google Scholar 

  • Seoane J, Varela-Centelles P, Ramirez JR, Romero MA, De La Cruz A. Artefacts produced by suture traction during incisional biopsy of oral lesions. Clin Otolaryngol Allied Sci. 2002;27(6):549–53.

    Article  PubMed  Google Scholar 

  • Seoane J, Varela-Centelles PI, Ramirez JR, Cameselle-Teijeiro J, Romero MA. Artefacts in oral incisional biopsies in general dental practice: a pathology audit. Oral Dis. 2004;10(2):113–7.

    Article  PubMed  Google Scholar 

  • Shokrollahi K, Raymond E, Murison MSC. Lasers: principles and surgical applications. J Surg. 2004;2(2):28–34.

    Article  Google Scholar 

  • Silverman EB, Read RW, Boyle CR, Cooper R, Miller WW, McLaughlin RM. Histologic comparison of canine skin biopsies collected using monopolar electrosurgery, CO2 laser, radiowave radiosurgery, skin biopsy punch, and scalpel. Vet Surg. 2007;36(1):50–6.

    Article  PubMed  Google Scholar 

  • Silverman RA. Hemangiomas and vascular malformations. Pediatr Clin N Am. 1991;38(4):811–34.

    Article  Google Scholar 

  • Singh Nanda KD, Mehta A, Nanda J. Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 2012;41(1):106–12.

    Article  PubMed  Google Scholar 

  • Sinha R, Sarkar S, Khaitan T, Kabiraj A, Maji A. Nonsurgical Management of Oral Mucocele by Intralesional Corticosteroid Therapy. Int J Dent. 2016;2016:2896748.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sinha UK, Gallagher LA. Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa. Laryngoscope. 2003;113(2):228–36.

    Article  PubMed  Google Scholar 

  • Sperandio M, Klinikowski MF, Brown AL, Shirlaw PJ, Challacombe SJ, Morgan PR, Warnakulasuriya S, Odell EW. Image-based DNA ploidy analysis aids prediction of malignant transformation in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121(6):643–50.

    Article  PubMed  Google Scholar 

  • Sridharan G, Shankar AA. Toluidine blue: a review of its chemistry and clinical utility. J Oral Maxillofac Pathol. 2012;16(2):251–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stanley MW. Selected problems in fine needle aspiration of head and neck masses. Mod Pathol. 2002;15(3):342–50.

    Article  PubMed  Google Scholar 

  • Suter VG, Altermatt HJ, Bornstein MM. A randomized controlled clinical and histopathological trial comparing excisional biopsies of oral fibrous hyperplasias using CO2 and Er:YAG laser. Lasers Med Sci. 2017;32(3):573–81.

    Article  PubMed  Google Scholar 

  • Suter VG, Altermatt HJ, Dietrich T, Reichart PA, Bornstein MM. Does a pulsed mode offer advantages over a continuous wave mode for excisional biopsies performed using a carbon dioxide laser? J Oral Maxillofac Surg. 2012;70(8):1781–8.

    Article  PubMed  Google Scholar 

  • Tozoglu S, Al-Belasy FA, Dolwick MF. A review of techniques of lysis and lavage of the TMJ. Br J Oral Maxillofac Surg. 2011;49(4):302–9.

    Article  PubMed  Google Scholar 

  • Tuncer I, Ozcakir-Tomruk C, Sencift K, Cologlu S. Comparison of conventional surgery and CO2 laser on intraoral soft tissue pathologies and evaluation of the collateral thermal damage. Photomed Laser Surg. 2010;28(1):75–9.

    Article  PubMed  Google Scholar 

  • van der Hem PS, Nauta JM, van der Wal JE, Roodenburg JL. The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up. Oral Oncol. 2005;41(1):31–7.

    Article  PubMed  Google Scholar 

  • van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncol. 2010;46(6):423–5.

    Article  PubMed  Google Scholar 

  • van der Waal RI, Schulten EA, van der Meij EH, van de Scheur MR, Starink TM, van der Waal I. Cheilitis granulomatosa: overview of 13 patients with long-term follow-up – results of management. Int J Dermatol. 2002;41(4):225–9.

    Article  PubMed  Google Scholar 

  • Vesnaver A, Dovsak DA. Treatment of vascular lesions in the head and neck using Nd:YAG laser. J Craniomaxillofac Surg. 2006;34(1):17–24.

    Article  PubMed  Google Scholar 

  • Vu A, Farah CS. Narrow band imaging: clinical applications in oral and oropharyngeal cancer. Oral Dis. 2016;22(5):383–90.

    Article  PubMed  Google Scholar 

  • Vu AN, Farah CS. Efficacy of narrow band imaging for detection and surveillance of potentially malignant and malignant lesions in the oral cavity and oropharynx: a systematic review. Oral Oncol. 2014;50(5):413–20.

    Article  PubMed  Google Scholar 

  • Vu AN, Matias M, Farah CS. Diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders. Oral Dis. 2015;21(4):519–29.

    Article  PubMed  Google Scholar 

  • Yeh CJ. Simple cryosurgical treatment for oral lesions. Int J Oral Maxillofac Surg. 2000;29(3):212–6.

    Article  PubMed  Google Scholar 

  • Yu CH, Lin HP, Cheng SJ, Sun A, Chen HM. Cryotherapy for oral precancers and cancers. J Formos Med Assoc. 2014;113(5):272–7.

    Article  PubMed  Google Scholar 

  • Zhang J, Li HB, Zhou SY, Chen KS, Niu CQ, Tan XY, Jiang YZ, Lin QQ. Comparison between absolute ethanol and bleomycin for the treatment of venous malformation in children. Exp Ther Med. 2013;6(2):305–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zheng JW, Yang XJ, Wang YA, He Y, Ye WM, Zhang ZY. Intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions: an evaluation of 297 consecutive patients. Oral Oncol. 2009;45(10):872–6.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Marieke T. Brands & Peter A. Brennan

  2. University of Zagreb School of Dental Medicine, Zagreb, Croatia

    Ivan Alajbeg

  3. UWA Dental School and Oral Health Centre of Western Australia, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia

    Camile S. Farah

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  1. Marieke T. Brands
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  2. Ivan Alajbeg
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  3. Peter A. Brennan
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  4. Camile S. Farah
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Correspondence to Marieke T. Brands .

Editor information

Editors and Affiliations

  1. UWA Dental School and Oral Health Centre of Western Australia, Faculty of Health and Medical Sciences University of Western Australia, Perth, WA, Australia

    Camile S. Farah

  2. UWA Dental School and Oral Health Centre of Western Australia, Faculty of Health and Medical Sciences University of Western Australia, Perth, WA, Australia

    Ramesh Balasubramaniam

  3. Oral Anatomy, Medicine, and Surgery Section Melbourne Dental School, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne, Carlton, VIC, Australia

    Michael J. McCullough

Section Editor information

  1. Oral Anatomy, Medicine, and Surgery Section, Melbourne, Dental School, Faculty of Medicine, Dentistry & Health, Sciences, The University of Melbourne, Carlton, VIC, Australia

    Michael J. McCullough

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Brands, M.T., Alajbeg, I., Brennan, P.A., Farah, C.S. (2019). Soft and Hard Tissue Operative Investigations in the Diagnosis and Treatment of Oral Disease. In: Farah, C., Balasubramaniam, R., McCullough, M. (eds) Contemporary Oral Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-72303-7_10

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  • DOI: https://doi.org/10.1007/978-3-319-72303-7_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-72301-3

  • Online ISBN: 978-3-319-72303-7

  • eBook Packages: MedicineReference Module Medicine

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