Definition
Antagonistic pleiotropy is an evolutionary theory of non-programmed aging, suggesting the presence of genes, the functioning of which is beneficial for the organism in the early stages of life but has negative effects in older ages. The term “antagonistic pleiotropy” means that a gene has several different effects of opposite value, but since the proposal of “antagonistic pleiotropy aging theory,” the term is often used as the name of this theory of aging.
Overview
Antagonistic pleiotropy aging theory was proposed by Williams in 1957 (Williams 1957). Already in its name two phenomena are mentioned, the presence of which is fundamental for it:
- (i)
Pleiotropy, i.e., the ability of one hereditary factor (gene) to influence several traits of the organism
- (ii)
The antagonism of pleiotropic effects, which can affect the fitness of the organism in an opposing way
An example of the manifestation of antagonistic pleiotropy may be a certain hypothetical gene, whose effect increases...
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Acknowledgments
Preparation of this work was supported by the Russian Science Foundation (Project No. 16-16-04032).
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Chistyakov, V.A., Denisenko, Y.V. (2019). Antagonistic Pleiotropy Aging Theory. In: Gu, D., Dupre, M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. https://doi.org/10.1007/978-3-319-69892-2_35-1
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DOI: https://doi.org/10.1007/978-3-319-69892-2_35-1
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