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Pulmonary Pathology pp 62–63Cite as

Amyloidosis, Tracheobronchial

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Part of the book series: Encyclopedia of Pathology ((EP))

Definition

In tracheobronchial amyloidosis, amyloid is deposited in various segments of the trachea and bronchi. The deposits are composed of amyloid light chains (AL) and confined to the tracheobronchial tree, representing a form of localized AL amyloidosis. Systemic or pulmonary parenchymal involvement is uncommon.

Clinical Features

  • Incidence

    Tracheobronchial amyloidosis constitutes a rare form of pulmonary amyloidosis; roughly 100 cases have been reported. Patients usually present with dyspnea, cough, hemoptysis, or hoarseness.

  • Age

    The mean age of patients with tracheobronchial amyloidosis is around 64 years.

  • Sex

    There is no sex predilection.

  • Site

    Tracheobronchial amyloidosis is typically confined to the tracheobronchial tree. Proximal, mid, and distal airway involvement has been described using computerized tomographic imaging and bronchoscopy.

  • Treatment

    The treatment depends on the localization of lesions and may include laser or forceps resection, external radiation, or...

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References and Further Reading

  • Borie, R., Danel, C., Molinier-Frenkel, V., Prevot, G., Deslee, G., Debray, M. P., Delfau-Larue, M. H., & Crestani, B. (2012). Tracheobronchial amyloidosis: Evidence for local B-cell clonal expansion. The European Respiratory Journal, 39(4), 1042–1045.

    Article  CAS  PubMed  Google Scholar 

  • Capizzi, S. A., Betancourt, E., & Prakash, U. B. (2000). Tracheobronchial amyloidosis. Mayo Clinic Proceedings, 75(11), 1148–1152.

    Article  CAS  PubMed  Google Scholar 

  • O’Regan, A., Fenlon, H. M., Beamis, J. F., Jr., Steele, M. P., Skinner, M., & Berk, J. L. (2000). Tracheobronchial amyloidosis. The Boston University experience from 1984 to 1999. Medicine (Baltimore), 79(2), 69–79.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA

    Andras Khoor

Authors
  1. Andras Khoor
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Corresponding author

Correspondence to Andras Khoor .

Editor information

Editors and Affiliations

  1. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA

    Philip T. Cagle

  2. Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Aberdeen, UK

    Keith M. Kerr

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Cite this entry

Khoor, A. (2018). Amyloidosis, Tracheobronchial. In: Cagle, P.T., Kerr, K.M. (eds) Pulmonary Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-69263-0_318

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  • DOI: https://doi.org/10.1007/978-3-319-69263-0_318

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-69262-3

  • Online ISBN: 978-3-319-69263-0

  • eBook Packages: MedicineReference Module Medicine

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