Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sarah SullivanEmail author
  • Weiguo Zhang
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_7

Historical Background

Engagement of the T cell receptor (TCR) with MHC-peptide complexes leads to the activation of protein tyrosine kinases (PTK), ultimately leading to the activation of downstream signaling events, such as calcium flux and mitogen-activated protein kinase (MAPK) activation (Chan et al. 1994). For many years, it was observed that a 36–38 kDa protein, localized to the plasma membrane, was highly tyrosine phosphorylated upon ligation of the TCR and associated with Grb2, PLC-γ1, and the p85 subunit of PI3K. It was hypothesized that this protein served as a critical link connecting TCR engagement at the membrane to activation of signaling events in the cytosol. In 1998, the gene encoding this protein was identified after microsequencing phosphorylated proteins purified from the membrane fractions of activated Jurkat T cells and was named LAT, linker for activation of Tcells. Sequencing of cDNA clones revealed that LAT is a type III transmembrane protein that contains a...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of ImmunologyDuke University Medical CenterDurhamUSA