RANK and RANKL
RANK and RANKL Family Members
RANK; receptor activator of nuclear factor-κB, TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, CD265. RANKL; receptor activator of nuclear factor-κB ligand, TNFSF11; tumor necrosis factor (ligand) superfamily, member 11, OPGL; osteoprotegerin ligand, ODF; osteoclast differentiation factor, TRANCE; TNF-related activation-induced cytokine, CD254.
In the late 1980s, an in vitro coculture system for osteoclast formation was established. This system was shown to require cell-to-cell contact between calvarial cells and bone marrow cells for osteoclast differentiation (Suda et al. 1999). Based on this finding, it was proposed that osteoclastogenesis-supporting mesenchymal lineage cells express an osteoclast differentiation factor (ODF) in the form of a membrane-associated protein (Suda et al. 1999). In the late 1990s, the potential inhibitor of osteoclastogenesis osteoprotegerin (OPG) was cloned. OPG is a decoy receptor...
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