Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Tomoki Nakashima
  • Hiroshi TakayanagiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_633

RANK and RANKL Family Members

RANK; receptor activator of nuclear factor-κB, TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, CD265. RANKL; receptor activator of nuclear factor-κB ligand, TNFSF11; tumor necrosis factor (ligand) superfamily, member 11, OPGL; osteoprotegerin ligand, ODF; osteoclast differentiation factor, TRANCE; TNF-related activation-induced cytokine, CD254.

Historical Background

In the late 1980s, an in vitro coculture system for osteoclast formation was established. This system was shown to require cell-to-cell contact between calvarial cells and bone marrow cells for osteoclast differentiation (Suda et al. 1999). Based on this finding, it was proposed that osteoclastogenesis-supporting mesenchymal lineage cells express an osteoclast differentiation factor (ODF) in the form of a membrane-associated protein (Suda et al. 1999). In the late 1990s, the potential inhibitor of osteoclastogenesis osteoprotegerin (OPG) was cloned. OPG is a decoy receptor...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Cell Signaling, Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) ProgramTakayanagi Osteonetwork ProjectTokyoJapan
  3. 3.Global Center of Excellence (GCOE) ProgramInternational Research Center for Molecular Science in Tooth and Bone DiseasesTokyoJapan