Reference work entry
WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) was initially identified in 2007 as a novel member of the WASP (Wiskott-Aldrich Syndrome Protein) superfamily of nucleation-promoting factors (NPFs) (Linardopoulou et al. 2007). In addition to WASH, this family includes the founding member WASP as well as N-WASP (Neuronal Wiskott–Aldrich Syndrome Protein), three WAVE/SCAR (WASP family Verprolin-homologous protein/Suppressor of cAR) isoforms, WHAMM (WASP Homolog associated with Actin, Membranes, and Microtubules), and JMY (Junction Mediating and Regulatory Protein) (Campellone and Welch 2010). WASH orthologs are evolutionarily conserved from humans through Entameba and WASH mRNA (Messenger RNA) is ubiquitously expressed in human tissues (Linardopoulou et al. 2007). Further work comparing known genome sequences revealed that WASH is conserved down to the green algae Ostreocuccus...
- Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, et al. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A. 2010;107:10442–7.PubMedPubMedCentralCrossRefGoogle Scholar
- Monfregola J, Napolitano G, D’urso M, Lappalainen P, Ursini MV. Functional characterization of Wiskott-Aldrich Syndrome Protein and Scar Homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and -Tubulin. J Biol Chem. 2010;285:16951–7.PubMedPubMedCentralCrossRefGoogle Scholar
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