Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sonia-Vanina ForcalesEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_622


Historical Background

MKK6 is a dual specificity mitogen-activated protein kinase that was first cloned by PCR using degenerate primers for the conserved kinase domain of MKKs (Han et al. 1996). MKK6 amino-acid sequence shares about 80% of similarity with MKK3 and 40% with MKK4 (Stein et al. 1996). Two MKK6 isoforms have been described in mouse and human (Cuenda et al. 1996; Han et al. 1996). The bigger isoform contains 334 amino acids and is highly expressed in heart, skeletal muscle, pancreas, and liver, while the smaller isoform of 278 amino acids has been detected only in skeletal muscle (Han et al. 1996).

Regulation of MKK6 Activity

Several extracellular stimuli initiate a signaling cascade of kinases that activate MKK6 by phosphorylating it at two residues (serine 207 and threonine 211) located in the activation loop domain (Fig. 1). The interaction of activation kinases with MKK6 is...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Germans Trias i Pujol Health Sciences Research Institute (IGTP), Program of Predictive and Personalized Medicine of Cancer (PMPPC)Badalona, BarcelonaSpain